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Keywords: Src
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Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
... membrane (INM) protein emerin. Accordingly, we determined the role of emerin in regulating fast amoeboid migration. Strikingly, we found that both the up- and downregulation of emerin results in an inhibition of fast amoeboid migration. However, when key Src phosphorylation sites were removed, upregulation...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (2): jcs254599.
Published: 25 January 2021
... (optoSRC) to control SRC signaling, an example of a pleiotropic signaling node, and we demonstrated its ability to generate different acto-adhesive structures (lamellipodia or invadosomes) upon distinct spatio-temporal control of SRC kinase activity. The occurrence of each acto-adhesive structure...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (23): 4013–4027.
Published: 1 December 2017
..., a phenotype observed in 2D polarized cells as well as 3D cysts. MT2-MMP-mediated cleavage subsequently disrupts apical E-cadherin-mediated cell quiescence resulting in relaxed apical cortical tension favoring cell extrusion and re-sorting of Src kinase activity to junctional complexes, thereby promoting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
...Weifeng Luo; Radoslav Janoštiak; Ondřej Tolde; Larisa M. Ryzhova; Lenka Koudelková; Michal Dibus; Jan Brábek; Steven K. Hanks; Daniel Rosel ABSTRACT The tyrosine kinase Src acts as a key regulator of cell motility by phosphorylating multiple protein substrates that control cytoskeletal and adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1064–1077.
Published: 15 March 2017
.... T. , Eschbacher , J. M. , Loftus , J. C. , Symons , M. H. and Tran , N. L. ( 2013 ). The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (16): 3130–3143.
Published: 15 August 2016
..., the host machinery that mediates amastigote uptake is poorly understood. We have previously shown that the Arg (also known as Abl2) non-receptor tyrosine kinase facilitates L. amazonensis amastigote uptake by macrophages. Using small-molecule inhibitors and primary macrophages lacking specific Src family...
Includes: Supplementary data
Journal Articles
In collection:
Imaging , Mitochondria
J Cell Sci (2016) 129 (14): 2707–2712.
Published: 15 July 2016
... this decapeptide regulates the tyrosine kinase Src, leading to reduced focal adhesion plaques and disruption of F-actin organisation. This strongly suggests that the N-terminus of survivin is a mitochondrial-targeting sequence that regulates Src, and that survivin acts in concert with Src to promote tumorigenesis...
Journal Articles
J Cell Sci (2016) 129 (1): 206–218.
Published: 1 January 2016
... adherens junctions is a common feature of these diseases, but the role of BMPs in this process has not been investigated. BMP signaling is initiated by binding of ligand to, and activation of, BMP type I (BMPRI) and type II (BMPRII) receptors. Internalization of VE-cadherin as well as c-Src kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3489–3501.
Published: 15 September 2015
... by Src, a non-receptor tyrosine kinase. In this mechanism, two concurrent distinct structural rearrangements of the cytosolic termini induce two opposing effects: upregulation of the single-channel open probability, mediated by an N-terminal tyrosine, and reduction in functional channels, mediated by a C...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (24): 5303–5316.
Published: 15 December 2014
... focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model). Here, we describe two new roles for Eps8. Firstly, it controls the spatial distribution of active Src in a FAK-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (16): 3440–3450.
Published: 15 August 2014
... photobleaching (FRAP) experiments reveal that CasSD phosphorylation, as opposed to the association of Cas with Src, facilitates Cas displacement from adhesion complexes in migrating cells. Furthermore, the stabilization of Src–Cas binding and inhibition of myosin II, both of which sustain CasSD phosphorylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1712–1725.
Published: 15 April 2014
...Karla C. Williams; Marc G. Coppolino ABSTRACT Acquisition of an invasive phenotype is prerequisite for tumor metastasis. Degradation of the extracellular matrix (ECM), and subsequent invasion by tumor cells, is mediated, in part, through subcellular structures called invadopodia. Src-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1684–1698.
Published: 15 April 2014
...James B. Reinecke; Dawn Katafiasz; Naava Naslavsky; Steve Caplan ABSTRACT Localization of the non-receptor tyrosine kinase Src to the cell periphery is required for its activation and to mediate focal adhesion turnover, cell spreading and migration. Inactive Src localizes to a perinuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (3): 509–520.
Published: 1 February 2014
... epithelial cells require cullin-5–RING–E3-ubiquitin-ligase complexes (Cul5-CRLs) to prevent transformation by a Src–Cas signaling pathway. Removal of Cul5 stimulates growth-factor-independent growth and migration, membrane dynamics and colony dysmorphogenesis, which are all dependent on the endogenous...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5541–5552.
Published: 15 December 2013
... junctions and VE-cadherin (also known as cadherin 5), and reduced Rho activation and stress fiber formation. In addition, NO deficiency reduced VEGF-induced VE-cadherin phosphorylation and impaired the localization, but not the activation, of c-Src to cell junctions. The physiological role of eNOS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (19): 4349–4357.
Published: 1 October 2013
... regulator of myogenesis, via activating TNFα-converting enzyme (TACE, also known as ADAM17), to release autocrine TNFα. However, the signaling mechanism of mechanical activation of TACE is unknown. Because TACE possesses the structural features of substrates of the non-receptor tyrosine kinase Src, we...
Journal Articles
J Cell Sci (2013) 126 (8): 1820–1831.
Published: 15 April 2013
... that PTP1B is required for efficient integrin-dependent downregulation of RhoA and upregulation of Rac1 during spreading. A substrate trap strategy revealed that FAK/Src recruitment and Src activity are essential for the generation of PTP1B substrates in adhesions. PTP1B targets the negative regulatory site...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 613–624.
Published: 15 January 2013
... endocytosis; FGF treatment increases the number of CCPs, including those undergoing endocytosis, and this effect is mediated by Src and its phosphorylation target Eps8. Eps8 interacts with the clathrin-mediated endocytosis machinery and depletion of Eps8 inhibits FGFR trafficking and immediate Erk signalling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 657–666.
Published: 15 January 2013
...Yi-Ru Pan; Ke-Huan Cho; Hsiao-Hui Lee; Zee-Fen Chang; Hong-Chen Chen Summary Podosomes are actin-enriched membrane protrusions that play important roles in extracellular matrix degradation and invasive cell motility. Podosomes undergo self-assembly into large rosette-like structures in Src...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 6185–6197.
Published: 15 December 2012
...Jason V. Evans; Amanda G. Ammer; John E. Jett; Chris A. Bolcato; Jason C. Breaux; Karen H. Martin; Mark V. Culp; Peter M. Gannett; Scott A. Weed Summary Tyrosine-kinase-based signal transduction mediated by modular protein domains is critical for cellular function. The Src homology (SH)2 domain...
Includes: Supplementary data