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Keywords: Splicing
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Journal Articles
J Cell Sci (2022) 135 (1): jcs259191.
Published: 7 January 2022
...Pablo Montañés-Agudo; Simona Casini; Simona Aufiero; Auriane C. Ernault; Ingeborg van der Made; Yigal M. Pinto; Carol Ann Remme; Esther E. Creemers ABSTRACT Eukaryotic genomes contain a tiny subset of ‘minor class’ introns with unique sequence elements that require their own splicing machinery...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs250688.
Published: 21 December 2020
... understood. Here, we show that Hub1-mediated alternative splicing of HEH1 pre-mRNA, resulting in production of its shorter form Heh1-S, is critical for the integrity of the NE in Saccharomyces cerevisiae . ESCRT-III mutants lacking Hub1 or Heh1-S display severe growth defects and accumulate improperly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs252551.
Published: 3 December 2020
... physically associates with the INQ substrate and splicing factor Hsh155, and regulates its assembly with partner proteins. Accordingly, cdc48 mutants have defects in splicing and show spontaneous distribution of Hsh155 to INQ aggregates, where it is stabilized. Overall, this study shows that Cdc48 regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs232728.
Published: 14 November 2019
...Cristina Moreno-Castro; Silvia Prieto-Sánchez; Noemí Sánchez-Hernández; Cristina Hernández-Munain; Carlos Suñé ABSTRACT Cajal bodies are nuclear organelles involved in the nuclear phase of small nuclear ribonucleoprotein (snRNP) biogenesis. In this study, we identified the splicing factor TCERG1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs224493.
Published: 25 April 2019
... matrix assembly. While the α integrin subunit determines extracellular ligand specificity, the β integrin chain binds to an acidic residue of the ligand, and cytoplasmic adapter protein families such as talins, kindlins and paxillin, to form mechanosensing cell matrix adhesions. Alternative splicing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (9): 1519–1531.
Published: 1 May 2017
... as tools to manipulate splicing and for use as potential anti-cancer drugs. We investigated the effects of these inhibitors on mRNA transport and stability in human cells. Upon splicing inhibition, unspliced pre-mRNAs accumulated in the nucleus, particularly within enlarged nuclear speckles. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3030–3040.
Published: 15 August 2015
...Karen S. Frese; Benjamin Meder; Andreas Keller; Steffen Just; Jan Haas; Britta Vogel; Simon Fischer; Christina Backes; Mark Matzas; Doreen Köhler; Vladimir Benes; Hugo A. Katus; Wolfgang Rottbauer ABSTRACT Alternative splicing is one of the major mechanisms through which the proteomic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (3): 311–320.
Published: 1 February 2011
... ( carla.green@utsouthwestern.edu ) © 2011. 2011 Circadian mRNA decay Translation Rhythmic mRNA stability Splicing The rotation of the earth creates a daily fluctuation of environmental cues. Organisms have evolved internal timing systems, called circadian clocks (see Box 1 for a glossary...
Journal Articles
J Cell Sci (2010) 123 (12): 2085–2093.
Published: 15 June 2010
...-immunoprecipitated with human RNA polymerase II from mitotic cell extracts and identified U1 small nuclear RNA (snRNA) as a major species. To investigate a possible splicing-independent recruitment of U1 snRNA to transcription units, we established cell lines having integrated a reporter gene containing a functional...
Journal Articles
J Cell Sci (2008) 121 (20): 3487–3495.
Published: 15 October 2008
... angiogenesis. Two families of VEGF isoforms are generated by alternate splice-site selection in the terminal exon. Proximal splice-site selection (PSS) in exon 8 results in pro-angiogenic VEGF xxx isoforms (xxx is the number of amino acids), whereas distal splice-site selection (DSS) results in anti-angiogenic...
Journal Articles
J Cell Sci (2007) 120 (2): 309–319.
Published: 15 January 2007
...Kate A. Sergeant; Cyril F. Bourgeois; Caroline Dalgliesh; Julian P. Venables; James Stevenin; David J. Elliott The scaffold attachment factor SAFB1 and its recently discovered homologue SAFB2 might provide an important link between pre-mRNA splicing, intracellular signalling and transcription...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2635–2641.
Published: 1 July 2006
...Anabella Srebrow; Alberto R. Kornblihtt Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control of their synthesis is required...
Journal Articles
J Cell Sci (2003) 116 (15): 3099–3107.
Published: 1 August 2003
... and comprises a histidine tail. A similar sequence is also responsible for the targeting of cyclin T1. Therefore the histidine-rich region represents a novel splicing speckle targeting signal. Moreover, overexpression of DYRK1A induces speckle disassembly. Such disassembly is DYRK1A activity specific, since...
Journal Articles
J Cell Sci (2001) 114 (16): 2911–2920.
Published: 15 August 2001
... to Prp2, the large subunit of the essential splicing factor U2AF. In wat1 mutants, the cellular amount of α-tubulin is decreased to very low levels, which results in compromised microtubules and spindles, consequently leading to unequal chromosome separation. Further analysis shows that, in spite...
Journal Articles
J Cell Sci (1995) 1995 (Supplement_19): 13–19.
Published: 1 January 1995
... will concentrate on the role played by the cap in pre-mRNA splicing and how it may contribute to efficient and specific substrate recognition. In the second half, we will discuss the roles that polyadenylation has been demonstated to play in RNA metabolism and will concentrate in particular on an elegant mechanism...