...Mi-seon Shin; Sang-ho Song; Jung Eun Shin; Seung-Hye Lee; Sung-Oh Huh; Dongeun Park ABSTRACT PAK-interacting guanine nucleotide exchange factor (βPix; also known as Arhgef7) has been implicated in many actin-based cellular processes, including spine morphogenesis in neurons. However, the molecular...

... negative regulator that has been identified for maturation of dendritic spines so far. Shedding of the ICAM-5 ectodomain promotes spine maturation and enhances synaptic activity. However, the mechanism by which ICAM-5 regulates spine development remains poorly understood. In this study, we found...

..., is upregulated during hippocampal long-term potentiation (LTP). Here, we show that activin increased the average number of presynaptic contacts on dendritic spines by increasing the population of spines that were contacted by multiple presynaptic terminals in cultured neurons. Activin also induced spine...

... of Biologists Limited 2001 2001 N -methyl- d -aspartate Hippocampus Dendrite Spine Excitotoxicity Varicosity Swelling Sodium Neuronal cell loss is a common symptom of numerous neurological disorders including Alzheimer’s disease, Parkinson’s disease, prion disease and Down’s syndrome...