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Keywords: Spindle-assembly checkpoint
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Journal Articles
J Cell Sci (2010) 123 (15): 2586–2595.
Published: 1 August 2010
... of this protein family referred to as RINGO C. We show that siRNA-mediated knockdown of RINGO C results in premature mitotic exit with misaligned chromosomes, even in the presence of microtubule poisons. Time-lapse-microscopy experiments suggest that RINGO C is involved in the spindle-assembly checkpoint (SAC...
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Proteostasis
J Cell Sci (2010) 123 (10): 1623–1633.
Published: 15 May 2010
... contributed equally to this work ‡ Authors for correspondence ( [email protected] ; [email protected] ) § These authors contributed equally to this work 31 3 2010 © 2010. 2010 Anaphase-promoting complex Spindle-assembly checkpoint E3 ubiquitin ligase Metaphase...
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Journal Articles
J Cell Sci (2010) 123 (6): 825–835.
Published: 15 March 2010
... the interaction between chromosomes and the plus-ends of dynamic spindle microtubules and control the timing of anaphase onset by regulating the spindle assembly checkpoint (SAC). There is much debate in the SAC research community as to whether mitotic cells sense only microtubule attachment at the kinetochore...
Journal Articles
J Cell Sci (2010) 123 (5): 653–659.
Published: 1 March 2010
...David Perera; Stephen S. Taylor Bub1 was one of the first protein kinases identified as a component of the spindle-assembly checkpoint, a surveillance mechanism that delays anaphase onset until all chromosomes are stably attached to spindle microtubules. Whereas the kinase activity of Bub1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 806–813.
Published: 1 March 2010
... Topoisomerase-IIα Cohesin Spindle-assembly checkpoint NoCut Faithful chromosome segregation requires that sister chromatids are held together from S phase, the time of DNA replication, to the moment in mitosis when all kinetochores have undergone bipolar attachment to spindle microtubules...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (23): 4188–4196.
Published: 1 December 2007
... of another cohesin subunit, Scc1 (Rad21, Mcd1), which allows the separation of sister chromatids. When anaphase onset is delayed by the spindle-assembly checkpoint, the complete removal of cohesin from chromosome arms but not from centromeres generates typical X- or V-shaped chromosomes. Here, we found...
Includes: Supplementary data