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Keywords: Spindle pole body
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Journal Articles
J Cell Sci (2021) 134 (19): jcs258972.
Published: 13 October 2021
... called the mitotic exit network (MEN), whose activation is triggered at spindle pole bodies (SPBs) by the Tem1 GTPase. Yet, MEN activity must be extinguished once MEN-dependent processes have been accomplished. One factor contributing to switching off the MEN is the Amn1 protein, which binds Tem1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (16): jcs253799.
Published: 23 August 2021
... the contribution of the spindle pole body (SPB; the centrosome equivalent in yeast) was specifically blocked during meiosis. Here, we demonstrate that this unexpected microtubule formation represents a bona fide type of acentrosomal spindle. Moreover, a comparative analysis of these self-assembled spindles...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2018) 131 (1): jcs210740.
Published: 4 January 2018
... or klp2 rescues temperature-sensitive cut7 mutants, deletion of only pkl1 can bypass the lethality caused by cut7 deletion. Pkl1 is tethered to the spindle pole body, whereas Klp2 is localized along the spindle microtubule. Forced targeting of Klp2 to the spindle pole body, however, compensates for Pkl1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4455–4465.
Published: 15 December 2016
... are tightly controlled, with inappropriate expression linked to oncogenesis. However, the mechanisms by which increased eEF1A expression alters cell behaviour are unknown. Our analyses in yeast suggest that elevation of eEF1A levels leads to stabilisation of the spindle pole body and changes in nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4429–4442.
Published: 15 October 2014
... by the forespore membrane (FSM), which is newly synthesized from spindle pole bodies (SPBs) in the cytoplasm of the mother cell as spore precursors. Although the coordination between meiosis and FSM assembly is vital for proper sporulation, the underlying mechanism remains unclear. In the present study, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (16): 3625–3640.
Published: 15 August 2014
...Sarah Wälde; Megan C. King ABSTRACT Defects in the biogenesis of the spindle pole body (SPB), the yeast centrosome equivalent, can lead to monopolar spindles and mitotic catastrophe. The KASH domain protein Kms2 and the SUN domain protein Sad1 colocalize within the nuclear envelope at the site...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5830–5839.
Published: 1 December 2012
...) cytoskeleton in three tip regions with a total of 13 nuclei and also the spindle microtubules of four mitotic nuclei. Each spindle pole body (SPB) nucleates three cMTs and most cMTs above a certain length grow according to their plus-end structure. Long cMTs closely align for several microns along the cortex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4218–4227.
Published: 15 November 2009
... of the γ-TuSC components eliminates the localization of all GCPs to the spindle pole body (SPB), whereas deletion of GCPD-GCPF does not affect localization of γ-TuSC components. Thus, GCPD-GCPF do not tether the γ-TuSC to the SPB, but, rather, the γ-TuSC tethers them to the SPB. GCPD-GCPF exhibit...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (3): 389–396.
Published: 22 January 2004
... of the FSM have been identified. Visualization of these proteins has demonstrated the dynamic nature of the genesis and development of the FSM. It begins to develop at the differentiated outer plaque of the spindle pole bodies (SPBs) and extends outwards, encapsulating each of the haploid nuclei produced...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (13): 2721–2735.
Published: 1 July 2003
... transcription is dependent on the meiosis-specific transcription factor Mei4. In meu14 Δ cells, the segregation and modification of the SPBs (spindle pole bodies) and microtubule elongation during meiosis II were aberrant. Meiotic meu14 Δ cells consequently produced a high frequency of abnormal tetranucleate...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (9): 1919–1929.
Published: 1 May 2002
...-nucleating surface is now exposed to the outside, whereas the former outside becomes buried inside. The new inner layer matures in late telophase. Thus, similar to mammals but unlike yeast where the new spindle pole body consists only of freshly assembled components( Adams and Kilmartin, 2000...
Journal Articles
J Cell Sci (2001) 114 (13): 2427–2435.
Published: 1 July 2001
.... In this process, each of the dispersed centromeres is often associated with a novel Sad1-containing body that is contacting a cytoplasmic microtubule laterally (Sad1 is a component of the spindle pole body (SPB)). The Sad1-containing body was colocalized with other known SPB components, Kms1 and Spo15...
Journal Articles
J Cell Sci (2001) 114 (2): 247–255.
Published: 15 January 2001
... into how cells link cellular polarity, spindle position and cell cycle progression. (e-mail: schuyler@fas.harvard.edu; david_pellman@dfci.harvard.edu ) © 2001 by Company of Biologists 2001 Mitosis Spindle orientation Centrosome Spindle pole body Microtubule Kinesin Dynein Actin...
Journal Articles
J Cell Sci (2000) 113 (10): 1695–1704.
Published: 15 May 2000
... typical of septation signalling network mutants. mob1p is located on both spindle pole bodies throughout mitosis. In addition it is also co-localised with the medial ring later in mitosis, and flanks the septum as the medial ring contracts. We also demonstrate that mob1p can be precipitated from cells...
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J Cell Sci (1998) 111 (18): 2809–2818.
Published: 15 September 1998
...Sylvie Souès; Ian R. Adams ABSTRACT The monoclonal antibody 78H6 recognises an 85 kDa component of the yeast spindle pole body. Here we identify and characterise this component as Spc72p, the product of YAL047C . The sequence of SPC72 contains potential coiled-coil domains; its overexpression...
Journal Articles
J Cell Sci (1998) 111 (17): 2607–2614.
Published: 1 September 1998
... functions in vivo: intra-astral motility of membranous organelles was not apparent; the rate and extent of spindle elongation during anaphase B were reduced; and spindle pole body separation almost stopped when the anaphase B spindle in the mutant was cut by a laser microbeam, demonstrating unequivocally...