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Keywords: Spindle pole body
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Journal Articles
J Cell Sci (2021) 134 (19): jcs258972.
Published: 13 October 2021
... called the mitotic exit network (MEN), whose activation is triggered at spindle pole bodies (SPBs) by the Tem1 GTPase. Yet, MEN activity must be extinguished once MEN-dependent processes have been accomplished. One factor contributing to switching off the MEN is the Amn1 protein, which binds Tem1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (16): jcs253799.
Published: 23 August 2021
... the contribution of the spindle pole body (SPB; the centrosome equivalent in yeast) was specifically blocked during meiosis. Here, we demonstrate that this unexpected microtubule formation represents a bona fide type of acentrosomal spindle. Moreover, a comparative analysis of these self-assembled spindles...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2018) 131 (1): jcs210740.
Published: 4 January 2018
... or klp2 rescues temperature-sensitive cut7 mutants, deletion of only pkl1 can bypass the lethality caused by cut7 deletion. Pkl1 is tethered to the spindle pole body, whereas Klp2 is localized along the spindle microtubule. Forced targeting of Klp2 to the spindle pole body, however, compensates for Pkl1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4455–4465.
Published: 15 December 2016
... are tightly controlled, with inappropriate expression linked to oncogenesis. However, the mechanisms by which increased eEF1A expression alters cell behaviour are unknown. Our analyses in yeast suggest that elevation of eEF1A levels leads to stabilisation of the spindle pole body and changes in nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4429–4442.
Published: 15 October 2014
... by the forespore membrane (FSM), which is newly synthesized from spindle pole bodies (SPBs) in the cytoplasm of the mother cell as spore precursors. Although the coordination between meiosis and FSM assembly is vital for proper sporulation, the underlying mechanism remains unclear. In the present study, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (16): 3625–3640.
Published: 15 August 2014
...Sarah Wälde; Megan C. King ABSTRACT Defects in the biogenesis of the spindle pole body (SPB), the yeast centrosome equivalent, can lead to monopolar spindles and mitotic catastrophe. The KASH domain protein Kms2 and the SUN domain protein Sad1 colocalize within the nuclear envelope at the site...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5830–5839.
Published: 1 December 2012
...) cytoskeleton in three tip regions with a total of 13 nuclei and also the spindle microtubules of four mitotic nuclei. Each spindle pole body (SPB) nucleates three cMTs and most cMTs above a certain length grow according to their plus-end structure. Long cMTs closely align for several microns along the cortex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4218–4227.
Published: 15 November 2009
... of the γ-TuSC components eliminates the localization of all GCPs to the spindle pole body (SPB), whereas deletion of GCPD-GCPF does not affect localization of γ-TuSC components. Thus, GCPD-GCPF do not tether the γ-TuSC to the SPB, but, rather, the γ-TuSC tethers them to the SPB. GCPD-GCPF exhibit...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2464–2472.
Published: 15 July 2009
... spindle pole bodies (SPB) at its ends. As the spindle elongates and the nucleus divides symmetrically, nuclear volume remains constant but nuclear area rapidly increases by 26%. When Ran-GTPase function is compromised in S. pombe , nuclear division is strikingly asymmetrical and the newly synthesized SPB...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (16): 3705–3716.
Published: 15 August 2005
... lethality in combination with the conventional kinesin mutation Δ kinA. By contrast, ApsB localized to spindle-pole bodies (the fungal centrosome), to septa and to spots moving rapidly along microtubules. The number of cytoplasmic microtubules was reduced in apsB mutants in comparison to the wild type...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (3): 389–396.
Published: 22 January 2004
... of the FSM have been identified. Visualization of these proteins has demonstrated the dynamic nature of the genesis and development of the FSM. It begins to develop at the differentiated outer plaque of the spindle pole bodies (SPBs) and extends outwards, encapsulating each of the haploid nuclei produced...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (13): 2721–2735.
Published: 1 July 2003
... transcription is dependent on the meiosis-specific transcription factor Mei4. In meu14 Δ cells, the segregation and modification of the SPBs (spindle pole bodies) and microtubule elongation during meiosis II were aberrant. Meiotic meu14 Δ cells consequently produced a high frequency of abnormal tetranucleate...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (9): 1919–1929.
Published: 1 May 2002
...) and is longer than the usual four to five heptads (see Discussion). E-mail: ralph.graef@lrz.uni-muenchen.de 16 2 2002 © The Company of Biologists Limited 2002 2002 Dictyostelium Centrosome Spindle pole body NIMA-related kinase Nek2 NIMA-related kinases are a ubiquitous...
Journal Articles
J Cell Sci (2001) 114 (13): 2427–2435.
Published: 1 July 2001
.... In this process, each of the dispersed centromeres is often associated with a novel Sad1-containing body that is contacting a cytoplasmic microtubule laterally (Sad1 is a component of the spindle pole body (SPB)). The Sad1-containing body was colocalized with other known SPB components, Kms1 and Spo15...