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Keywords: Spindle pole
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Journal Articles
J Cell Sci (2020) 133 (10): jcs239723.
Published: 27 May 2020
...-licence-1-1/ Summary: CSAG1, a novel regulator of mitosis that constrains the pericentriolar material to prevent spindle pole fragmentation, particularly, in cells that lack p53 function. Cell cycle Spindle pole Multipolar mitosis Aneuploidy Pericentriolar matrix Mitosis...
Includes: Supplementary data
Journal Articles
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J Cell Sci (2019) 132 (11): jcs227850.
Published: 7 June 2019
... and interactions with partners, such as microtubule severing enzymes, microtubule depolymerases and protein scaffolds. Together with minus-end-directed motors, these microtubule minus-end targeting proteins (−TIPs) also control the formation of microtubule-organizing centers, such as centrosomes and spindle poles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 5096–5109.
Published: 1 November 2012
... formation and positioning that is required for mitotic progression and cell fate determination. WD40-repeat protein 62 (WDR62) was recently identified as a spindle pole protein linked to the neurodevelopmental defect of microcephaly but its roles in mitosis have not been defined. We report here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (3): 338–347.
Published: 1 February 2011
..., we characterize CEP90 as a component of pericentriolar satellites. CEP90 is present both in the centrosome and in the cytoplasm, but is transiently concentrated at the centrosome once cells enter mitosis. Depletion of CEP90 caused mitotic arrest with misaligned chromosomes. Spindle pole fragmentation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (23): 5557–5566.
Published: 1 November 2004
... cellular microtubules and MTOC with antibodies specific to β-tubulin and γ-tubulin, respectively ( Fig. 7A ). Distinct MTOCs near nuclei were observed in blastomeres of the control embryos ( Fig. 7A ) ( Houliston et al., 1987 ; Meng et al., 2004 ). Spindle poles in the mitotic blastomere looked focused...
Journal Articles
J Cell Sci (2003) 116 (16): 3399–3411.
Published: 15 August 2003
...-binding protein 1 (RanBP1), a major effector of Ran, induces multipolar spindles. We now show that these abnormal spindles are generated through loss of cohesion in mitotic centrosomes. Specifically,RanBP1 excess induces splitting of mother and daughter centrioles at spindle poles; the resulting split...
Journal Articles
J Cell Sci (2003) 116 (13): 2635–2646.
Published: 1 July 2003
... the spindle poles,suggesting a role of centrin in tethering basal bodies to the spindle. To test whether an association with the spindle poles is required for correct basal body segregation, we disrupted centrin fibers in wild-type cells by over-expressing a nonfunctional centrin-GFP. In these cells, basal...
Journal Articles
J Cell Sci (2002) 115 (9): 1815–1824.
Published: 1 May 2002
...Laurence Haren; Andreas Merdes In mitosis, NuMA localises to spindle poles where it contributes to the formation and maintenance of focussed microtubule arrays. Previous work has shown that NuMA is transported to the poles by dynein and dynactin. So far, it is unclear how NuMA accumulates...