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Keywords: Spindle checkpoint
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Journal Articles
J Cell Sci (2015) 128 (8): 1639–1653.
Published: 15 April 2015
...Michiel Boekhout; Rob Wolthuis Nek2 isoform A (Nek2A) is a presumed substrate of the anaphase‐promoting complex/cyclosome containing Cdc20 (APC/C Cdc20 ). Nek2A, like cyclin A, is degraded in mitosis while the spindle checkpoint is active. Cyclin A prevents spindle checkpoint proteins from binding...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4197–4206.
Published: 15 September 2012
...Scott C. Schuyler; Yueh-Fu Wu; Vivian Jen-Wei Kuan Summary Cancer cells are commonly aneuploid. The spindle checkpoint ensures accurate chromosome segregation by controlling cell cycle progression in response to aberrant microtubule–kinetochore attachment. Damage to the checkpoint, which...
Journal Articles
J Cell Sci (2010) 123 (1): 84–94.
Published: 1 January 2010
... ). Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1. Exp. Cell Res. 312 , 1831 -1842. Ditchfield, C., Johnson, V. L., Tighe, A., Ellston, R., Haworth, C., Johnson, T., Mortlock, A., Keen, N. and Taylor, S. S. ( 2003 ). Aurora B couples chromosome...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3831–3836.
Published: 1 November 2009
... Limited 2009 2009 Mitosis Microtubules Spindle checkpoint The accurate segregation of genetic material between daughter cells is an essential step in cell division. Errors in this process lead to aneuploidy and can result in cell transformation ( King, 2008 ). The kinetochore is a network...
Journal Articles
J Cell Sci (2009) 122 (15): 2579–2585.
Published: 1 August 2009
... The Company of Biologists Limited 2009 2009 Taxol Paclitaxel Spindle checkpoint Drugs that disrupt mitotic progression, which are commonly referred to as `anti-mitotics', are used extensively for the treatment of cancer. Currently, all such drugs that have been approved for clinical use target...
Journal Articles
Journal Articles
J Cell Sci (2007) 120 (20): 3522–3533.
Published: 15 October 2007
... Limited 2007 2007 Aneuploidy Spindle checkpoint Chromosome congression Mono-oriented chromosomes Among the cellular structures most responsible for the accurate distribution of chromosomes during cell division are the centromeres and their associated kinetochores. Centromeres...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (16): 2807–2818.
Published: 15 August 2007
...Rahul Pandey; Sebastian Heeger; Christian F. Lehner The dramatic chromosome instability in certain tumors might reflect a synergy of spindle checkpoint defects with hypoxic conditions. In Caenorhabditis elegans and Drosophila melanogaster , spindle checkpoint activation has been implicated...
Journal Articles
J Cell Sci (2005) 118 (17): 3849–3859.
Published: 1 September 2005
... formation with normal timings; while both securin and cyclin B1 destruction, visualised by coupling to fluorescent protein tags, were complete by the time of polar body extrusion. Induction of a spindle checkpoint by overexpression of Mad2 or by spindle poisons blocked CamKII-induced resumption of meiosis...
Journal Articles
J Cell Sci (2005) 118 (16): 3639–3652.
Published: 15 August 2005
...Christopher J. Morrow; Anthony Tighe; Victoria L. Johnson; Maria I.F. Scott; Claire Ditchfield; Stephen S. Taylor The spindle checkpoint maintains genome stability by inhibiting Cdc20-mediated activation of the anaphase promoting complex/cyclosome (APC/C) until all the chromosomes correctly align...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (18): 4033–4042.
Published: 15 August 2004
..., the protein appears to modulate microtubule function and might participate in regulating the spindle checkpoint. Survivin physically associates with Aurora B, a serine-threonine kinase involved in microtubule attachment to centromeres and regulation of chromosome segregation. Here we have examined...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (2): 199–209.
Published: 15 January 2004
... evoke the mitotic spindle checkpoint response. Whereas premature mitotic exit is dependent upon anaphase promoting complex function, premature spindle elongation is not. We conclude that nimU is constitutively required for orderly mitotic progression under normal growth conditions and also required...
Journal Articles
J Cell Sci (2003) 116 (4): 617–628.
Published: 15 February 2003
...Leigh Campbell; Kevin G. Hardwick The spindle checkpoint delays the onset of anaphase if there are any defects in the interactions between spindle microtubules and kinetochores. This checkpoint has been reconstituted in vitro in Xenopus egg extracts, and here we use antibodies to Xenopus Bub3...
Journal Articles
J Cell Sci (2002) 115 (19): 3787–3795.
Published: 1 October 2002
...Julie C. Canman; Nitin Sharma; Aaron Straight; Katie B. Shannon; Guowei Fang; E. D. Salmon Spindle checkpoint proteins, such as Mad2 and BubR1, and the motors dynein/dynactin and CENP-E usually leave kinetochores prior to anaphase onset by microtubule-dependent mechanisms. Likewise, `chromosome...
Journal Articles
J Cell Sci (2002) 115 (8): 1603–1610.
Published: 15 April 2002
...Amy E. Ikui; Kanji Furuya; Mitsuhiro Yanagida; Tomohiro Matsumoto To ensure accurate chromosome segregation, the spindle checkpoint delays the onset of sister chromatid separation when the spindle is not attached to a kinetochore. Mad2, a component of the checkpoint, targets fission yeast Slp1...
Journal Articles
J Cell Sci (2001) 114 (24): 4385–4395.
Published: 15 December 2001
... and Glaxo SmithKline. References Amon, A. ( 1999 ). The spindle checkpoint. Curr. Opin. Genet. Dev . 9 , 69 -75. Basu, J., Logarinho, E., Herrmann, S., Bousbaa, H., Li, Z., Chan, G. K., Yen, T. J., Sunkel, C. E. and Goldberg, M. L. ( 1998 ). Localization of the Drosophila checkpoint...
Journal Articles
J Cell Sci (2001) 114 (23): 4173–4183.
Published: 1 December 2001
...R. Bruce Nicklas; Jennifer C. Waters; E. D. Salmon; Suzanne C. Ward The spindle checkpoint detects errors in kinetochore attachment to microtubules and delays anaphase if attachment is improper. The checkpoint is activated by attachment-sensitive components including Mad2 and certain phosphorylated...
Journal Articles
J Cell Sci (2001) 114 (12): 2345–2354.
Published: 15 June 2001
... and also Lte1. Following spindle checkpoint activation, the cell cycle phosphorylation of Bfa1 and Lte1 is protracted and some species are accentuated. Thus, the Bub2-dependent pathway is active every cell cycle and the effect of spindle damage is simply to protract its normal function. Indeed, function...