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Keywords: Spermiogenesis
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Journal Articles
J Cell Sci (2022) 135 (3): jcs259036.
Published: 2 February 2022
... maintained under specific pathogen-free conditions according to the guidelines of the Institutional Animal Care and Use Committee of Nanjing Medical University. Collectively, we postulate that TCFL5 plays an important role in spermiogenesis via two pathways: one in the regulation of Scml2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (21): jcs259206.
Published: 1 November 2021
... results in fertility defects that are secondary to abnormalities in acrosome biogenesis during spermiogenesis, reminiscent of globozoospermia. Analysis of the FAM209 proteome identified DPY19L2, whose human orthologue is involved in the majority of globozoospermia cases. Although mutations in human...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (17): 2854–2866.
Published: 1 September 2017
... translation of Tnp2 and Prm2 , leading to arrested differentiation in mouse spermatids. Spermatogenesis Spermiogenesis Chromatoid body Protamine Transition protein Inositol hexakisphosphate kinase Inositol hexakisphosphate kinases (IP6Ks) are evolutionarily conserved inositol phosphate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1835–1844.
Published: 15 May 2017
...Kula N. Jha; Swamy K. Tripurani; Gibbes R. Johnson ABSTRACT Spermiogenesis includes transcriptional silencing, chromatin condensation and extensive morphological changes as spermatids transform into sperm. Chromatin condensation involves histone hyperacetylation, transitory DNA breaks, histone H2AX...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 492–501.
Published: 1 February 2016
.... Huntingtin Spermiogenesis Translation Spermatogenesis DNA packaging The human Huntingtin gene ( HTT ) is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal and cortical neurons ( Gil and Rego, 2008 ). Given that expansion of a CAG triplet...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 923–934.
Published: 1 March 2015
... Spermiogenesis Approximately 10–15% of couples worldwide are affected by reduced fertility, and in roughly half of these cases the defects can be traced to the men ( WHO, 1999 ; Jarow et al., 2002 ). A large proportion of infertile men have defects in the process of spermatogenesis (spermatogenetic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3204–3213.
Published: 15 July 2013
... infertile. The Cetn1 −/− testes size was normal, and spermatogonia as well as spermatocytes developed normally. However, spermatids lacked tails suggesting severe defects at the late maturation phase of spermiogenesis. Viable sperm cells were absent and the few surviving spermatozoa were malformed. Light...
Includes: Supplementary data