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Keywords: Spermatogenesis
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Journal Articles
J Cell Sci (2022) 135 (4): jcs259196.
Published: 22 February 2022
... to the definitions outlined previously ( Russel et al., 1990 ), using a combination of SYCP3 and DAPI staining, and are further outlined in Fig. S1A . As Adad2 M/M males do not complete spermatogenesis, staging was reliant on cell types present prior to ADAD2 expression, primarily preleptotene, leptotene...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (3): jcs259036.
Published: 2 February 2022
... that mediates DNA and RNA to regulate spermatogenesis. This article has an associated First Person interview with the first author of the paper. SDS-PAGE gels were dipped in R250 dye solution for 3 h at room temperature with gentle rocking and then washed in washing buffer until the gels became transparent...
Includes: Supplementary data
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Stem cells
J Cell Sci (2021) 134 (14): jcs258757.
Published: 22 July 2021
... for correspondence ( yukikomy@wi.mit.edu ) Highlighted Article: me31B is identified as a negative regulator of dedifferentiation from spermatogonia to germline stem cells in the Drosophila testis via its ability to downregulate nos expression. Dedifferentiation Spermatogenesis Drosophila...
Includes: Supplementary data
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Mitochondria
J Cell Sci (2020) 133 (14): jcs235937.
Published: 16 July 2020
.... Less is known about the role of mitochondrial dynamics in developmental systems that involve changes in metabolic function. One such system is spermatogenesis. The first mitochondrial dynamics gene, Fuzzy onions ( Fzo ), was discovered in 1997 to mediate mitochondrial fusion during Drosophila...
Journal Articles
J Cell Sci (2019) 132 (14): jcs229849.
Published: 15 July 2019
... and reproduction in any medium provided that the original work is properly attributed. Summary: The quiescent and differentiated state of Sertoli cells during spermatogenesis depends on negative regulation of E2F3 by retinoblastoma protein, which maintains cell cycle exit and terminal differentiation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs217125.
Published: 3 September 2018
...So Maezawa; Kazuteru Hasegawa; Kris G. Alavattam; Mayuka Funakoshi; Taiga Sato; Artem Barski; Satoshi H. Namekawa ABSTRACT Spermatogenesis involves the progressive reorganization of heterochromatin. However, the mechanisms that underlie the dynamic remodeling of heterochromatin remain unknown. Here...
Includes: Supplementary data
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Imaging
J Cell Sci (2017) 130 (17): 2854–2866.
Published: 1 September 2017
..., causes sterility in male mice. Here, we present a detailed investigation of the specific function of IP6K1 in spermatogenesis. Within the mouse testis, IP6K1 is expressed at high levels in late stage pachytene spermatocytes and in round spermatids. We found IP6K1 to be a novel component of the chromatoid...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (3): 492–501.
Published: 1 February 2016
... fertility, providing evidence for a link between Htt and spermatogenesis; however, the underlying mechanism remains unclear. To understand better the function of Htt in spermatogenesis, we restricted the genetic deletion specifically to the germ cells using the Cre/ loxP site-specific recombination strategy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1969–1981.
Published: 15 May 2015
... or financial interests. 17 12 2014 18 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 Drosophila melanogaster Telomere Capping protein Male germline Spermatogenesis Telomeres are specialized structures that organize the extremities of linear chromosomes...
Journal Articles
J Cell Sci (2014) 127 (22): 4870–4882.
Published: 15 November 2014
.... 25 02 2014 1 09 2014 © 2014. Published by The Company of Biologists Ltd 2014 Testis rpS6 Blood–testis barrier Spermatogenesis Seminiferous epithelial cycle Sertoli cells Germ cell transport F-actin Ectoplasmic specialization Tight junction In the mammalian testis...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (17): 3927–3938.
Published: 1 September 2013
..., and the protein was found associated with the XY body. As complete loss of RAD9A is embryonic lethal, we constructed and characterized a mouse strain with Stra8-Cre driven germ cell-specific ablation of Rad9a beginning in undifferentiated spermatogonia in order to assess its role in spermatogenesis. Adult mutant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3095–3104.
Published: 15 July 2013
...Emad A. Ahmed; Agnel Sfeir; Hiroyuki Takai; Harry Scherthan Summary Spermatogenesis is a complex process that generates haploid germ cells or spores and implements meiosis, a succession of two special cell divisions that are required for homologous chromosome segregation. During prophase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (18): 3137–3148.
Published: 15 September 2011
... differentiation in the testis and for sustained spermatogenesis. Stem cells are fundamental for the regenerative capacity of organ systems ( Dick, 2008 ). They are characterized by having the potential to self-renewal and to differentiate. The mechanisms regulating the balance between these processes remain...
Includes: Supplementary data
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Journal Articles
Journal Articles
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Lipid biology
J Cell Sci (2009) 122 (16): 2866–2876.
Published: 15 August 2009
... of constitutive secretion at lower temperature. Our findings point to an essential role of FetA in Golgi morphology and secretory function, suggesting a crucial role for this novel murine P4-ATPase in spermatogenesis. P4-ATPases are transmembrane proteins unique to eukaryotes that recently have been linked...
Journal Articles
J Cell Sci (2009) 122 (15): 2686–2698.
Published: 1 August 2009
... that the enlarged irregular nuclei (seen in Fig. 3B ) are interkinesis nuclei that are generated by a failure of the first meiotic division but otherwise normal chromosome development. These observations suggest that earlier stages of spermatogenesis up to metaphase I are unaffected in TG Rec8-N-Myc cells...
Includes: Multimedia, Supplementary data