..., and is a key heterochromatin maintenance factor in male germ cells. Chromatin Germ cells Meiosis RNA-binding proteins mRNA translation Spermatogenesis Eunice Kennedy Shriver National Institute of Child Health and Human Development http://dx.doi.org/10.13039/100009633 R00 HD083521...

... that mediates DNA and RNA to regulate spermatogenesis. This article has an associated First Person interview with the first author of the paper. SDS-PAGE gels were dipped in R250 dye solution for 3 h at room temperature with gentle rocking and then washed in washing buffer until the gels became transparent...

... regulator of dedifferentiation from spermatogonia to germline stem cells in the Drosophila testis via its ability to downregulate nos expression. Dedifferentiation Spermatogenesis Drosophila Germ cells Howard Hughes Medical Institute http://dx.doi.org/10.13039/100000011...

.... Less is known about the role of mitochondrial dynamics in developmental systems that involve changes in metabolic function. One such system is spermatogenesis. The first mitochondrial dynamics gene, Fuzzy onions ( Fzo ), was discovered in 1997 to mediate mitochondrial fusion during Drosophila...

... and reproduction in any medium provided that the original work is properly attributed. Summary: The quiescent and differentiated state of Sertoli cells during spermatogenesis depends on negative regulation of E2F3 by retinoblastoma protein, which maintains cell cycle exit and terminal differentiation...

...So Maezawa; Kazuteru Hasegawa; Kris G. Alavattam; Mayuka Funakoshi; Taiga Sato; Artem Barski; Satoshi H. Namekawa ABSTRACT Spermatogenesis involves the progressive reorganization of heterochromatin. However, the mechanisms that underlie the dynamic remodeling of heterochromatin remain unknown. Here...

..., causes sterility in male mice. Here, we present a detailed investigation of the specific function of IP6K1 in spermatogenesis. Within the mouse testis, IP6K1 is expressed at high levels in late stage pachytene spermatocytes and in round spermatids. We found IP6K1 to be a novel component of the chromatoid...

...Sunghee Yoon; Ichiro Kawasaki; Yhong-Hee Shim ABSTRACT Depletion of cyb-1 , a major B-type cyclin expressed during Caenorhabditis elegans spermatogenesis, causes a meiotic division arrest in diakinesis-stage spermatocytes with multiple and mispositioned centrosomes. Association of the two nuclear...

... fertility, providing evidence for a link between Htt and spermatogenesis; however, the underlying mechanism remains unclear. To understand better the function of Htt in spermatogenesis, we restricted the genetic deletion specifically to the germ cells using the Cre/ loxP site-specific recombination strategy...

... or financial interests. 17 12 2014 18 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 Drosophila melanogaster Telomere Capping protein Male germline Spermatogenesis Telomeres are specialized structures that organize the extremities of linear chromosomes...

.... 25 02 2014 1 09 2014 © 2014. Published by The Company of Biologists Ltd 2014 Testis rpS6 Blood–testis barrier Spermatogenesis Seminiferous epithelial cycle Sertoli cells Germ cell transport F-actin Ectoplasmic specialization Tight junction In the mammalian testis...

... and spermatogenesis. * These authors contributed equally to this work ‡ Author for correspondence ( sdalal@actrec.gov.in ) Competing interests The authors declare no competing interests. 18 12 2012 31 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 14-3-3γ...

..., and the protein was found associated with the XY body. As complete loss of RAD9A is embryonic lethal, we constructed and characterized a mouse strain with Stra8-Cre driven germ cell-specific ablation of Rad9a beginning in undifferentiated spermatogonia in order to assess its role in spermatogenesis. Adult mutant...

...Emad A. Ahmed; Agnel Sfeir; Hiroyuki Takai; Harry Scherthan Summary Spermatogenesis is a complex process that generates haploid germ cells or spores and implements meiosis, a succession of two special cell divisions that are required for homologous chromosome segregation. During prophase...

... differentiation in the testis and for sustained spermatogenesis. Stem cells are fundamental for the regenerative capacity of organ systems ( Dick, 2008 ). They are characterized by having the potential to self-renewal and to differentiate. The mechanisms regulating the balance between these processes remain...

... spermatogenesis. Production of spag4 mRNA is limited to the testis, and Spag4 protein shows a dynamic pattern of association with the germline nuclei, including a concentration of protein at the site of attachment of the single spermatid centriole. In the absence of Spag4, nuclei and centrioles or basal bodies...

... differentiation. * Author for correspondence ( dolci@uniroma2.it ) 9 12 2009 © 2010. 2010 NANOS2 FGF9 RA Gata2 Taf7l Meiosis Spermatogenesis Nanos is an evolutionarily conserved protein that is essential for the survival of primordial germ cells (PGCs). It has been shown...

... to haploid gene expression, in mammalian round spermatids. However, little is known about functions and fate of the CB at later steps of spermatogenesis, when elongating spermatids undergo chromatin compaction and transcriptional silencing. In mouse elongating spermatids, we detected accumulation...

... of constitutive secretion at lower temperature. Our findings point to an essential role of FetA in Golgi morphology and secretory function, suggesting a crucial role for this novel murine P4-ATPase in spermatogenesis. § Authors for correspondence ( xyding@sunm.shcnc.ac.cn ; tgp@life.ku.dk...

.... These observations suggest that earlier stages of spermatogenesis up to metaphase I are unaffected in TG Rec8-N-Myc cells and that the first abnormality appears between metaphase I and the interkinesis stages. The large interkinesis and spermatid nuclei and the accumulation of cells with a 4C DNA content suggest...