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Keywords: Spectrin
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Journal Articles
J Cell Sci (2020) 133 (15): jcs248583.
Published: 5 August 2020
...Ru Jia; Yongping Chai; Chao Xie; Gai Liu; Zhiwen Zhu; Kaiyao Huang; Wei Li; Guangshuo Ou ABSTRACT Perturbation of spectrin-based membrane mechanics causes hereditary elliptocytosis and spinocerebellar ataxia, but the underlying cellular basis of pathogenesis remains unclear. Here, we introduced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs222042.
Published: 29 November 2018
... of the spectrin–F-actin and α-actinin–F-actin networks at the membrane. These rearranged F-actin networks appear to be less able to support mechanical load and resilience, leading to an overall change in tissue mechanical properties. This is the first in vivo evidence that a Tpm protein is essential for cell...
Includes: Supplementary data
Journal Articles
In collection:
J Cell Sci (2016) 129 (13): 2651–2659.
Published: 1 July 2016
... remains unclear. Here, we examine the hierarchy of events during cytoskeletal polarisation in Drosophila melanogaster epithelia. Core apical-basal polarity determinants polarise the spectrin cytoskeleton to recruit the microtubule-binding proteins Patronin (CAMSAP1, CAMSAP2 and CAMPSAP3 in humans...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (3): 743–750.
Published: 1 February 2012
... the distance between them. Relative to other probes, it is physically smaller and exhibits a greater dynamic range and sensitivity and expresses well. For in vivo testing, we measured stress gradients in time and space in non-erythroid spectrin in several different cell types and found that spectrin is under...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 2914–2926.
Published: 1 September 2011
... -spectrin (β H ) and the multivesicular body (MVB) in Drosophila . AnxB9 binds to a subset of β H spliceoforms, and loss of AnxB9 results in an increase in basolateral β H and its appearance on cytoplasmic vesicles that overlap with the MVB markers Hrs, Vps16 and EPS15. Similar colocalizations are seen when...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (2): 277–285.
Published: 15 January 2010
.... Roughest and the cadherin-based zonula adherens (ZA) are interdependent and both are modulated by the apical polarity determinant, Crumbs. Here we describe a novel relationship between the Crumbs partner β Heavy -spectrin (β H ), the ZA and Roughest. Ectopic expression of the C-terminal segment 33 of β H...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1091–1099.
Published: 15 April 2009
...Qiaozhen Kang; Ting Wang; Huizheng Zhang; Narla Mohandas; Xiuli An The archetypal membrane skeleton is that of the erythrocyte, consisting predominantly of spectrin, actin, ankyrin R and protein 4.1R. The presence in the Golgi of a membrane skeleton with a similar structure has been inferred, based...
Journal Articles
J Cell Sci (2007) 120 (22): 3999–4008.
Published: 15 November 2007
..., as well as increased plasma creatine kinase levels. Costameres at the sarcolemma of keratin-19-null muscle, visualized with antibodies against spectrin or dystrophin, were disrupted and the sarcolemma was separated from adjacent myofibrils by a large gap in which mitochondria accumulated. The costameric...
Journal Articles
J Cell Sci (2007) 120 (20): 3625–3632.
Published: 15 October 2007
..., and a decrease in epithelial cell height, without effects on localisation of tight junction or adherens junction proteins, or any apparent changes in cell-cell adhesion. Instead, distribution of αII-spectrin on lateral membranes is disrupted upon reduction of Tmod3 levels, suggesting that loss of Tmod3 function...
Journal Articles
J Cell Sci (2006) 119 (7): 1361–1370.
Published: 1 April 2006
...Matthew D. Phillips; Graham H. Thomas An apical brush border is a characteristic of many mature epithelia. This dynamic structure consists of dense microvilli supported by F-actin bundles that protrude into the apical cytoplasm, where they are crosslinked by spectrin and myosin II to form...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (2): 381–395.
Published: 15 January 2005
...Katarzyna Bialkowska; Takaomi C. Saido; Joan E. B. Fox In this study, we used cultured cells spreading on β3 integrin substrates to examine the possibility that spectrin is involved in signal transduction. Spectrin clustered with specialized calpain-induced β3 integrin signaling complexes...
Journal Articles
J Cell Sci (2004) 117 (5): 771–782.
Published: 15 February 2004
... polarized membrane domain. The spectrin-based membrane skeleton is thought to contribute to such stabilization by increasing the half-life of many proteins at the cell surface. Genetic evidence is consistent with a negative role for Drosophila β Heavy -spectrin in endocytosis, but the inhibitory mechanism...
Journal Articles
J Cell Sci (2004) 117 (4): 619–629.
Published: 1 February 2004
...Jun Fan; Kenneth A. Beck Expression of a dominant negative fragment of the spectrin family member Syne-1 causes an accumulation of binucleate cells, suggesting a role for this protein in cytokinesis. An association of this fragment with the C-terminal tail domain of the kinesin II subunit KIF3B...
Journal Articles
J Cell Sci (2002) 115 (22): 4215–4225.
Published: 15 November 2002
... the fact that they share features with both the spectrin and plakin superfamilies. These genes produce a variety of large proteins, up to almost 9000 residues long, which can potentially extend 0.4 μm across a cell. Spectraplakins can interact with all three elements of the cytoskeleton: actin...
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 101–108.
Published: 1 December 1993
... intermediate in the pathway of pathogenesis leading to neuronal loss. Key words: membrane-cytoskeleton linkage, spectrin, ankyrin, cell adhesion molecule, Ig-super family INTRODUCTION Neurofilaments are 10 nm filaments in many types o f neu­ rons. Assembled from three polypeptide subunits, NF-L (68 kDa), NF-M...
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 109–117.
Published: 1 December 1993
... words: cell adhesion molecule, ankyrin, spectrin, membrane- cytoskeletal interaction INTRODUCTION This article will focus on recent biochemical evidence for a direct association between a family of membrane-span­ ning cell adhesion molecules and ankyrins in the adult ner­ vous system of mammals...