... HES5 directly regulates Sox9 transcription to coordinate cartilage development. HEY1 and HEYL play no discernable role in regulating chondrogenesis or chondrocyte hypertrophy, whereas none of the HES or HEY factors appear to mediate Notch regulation of cartilage matrix catabolism. This work identifies...

...Wentao Deng; Daniel B. Vanderbilt; Chen-Chung Lin; Karen H. Martin; Kathleen M. Brundage; J. Michael Ruppert ABSTRACT The high mobility group box protein SOX9 and the GLI1 transcription factor play protumorigenic roles in pancreatic ductal adenocarcinoma (PDA). In Kras transgenic mice, each...

... of the articular cartilage. We found reduced Col2a1 and Acan expression, but increased Mmp13 and Adamts5 expression, in Tak1 -deficient chondrocytes along with reduced expression of the SOX trio of transcription factors, SOX9, SOX5 and SOX6. In vitro , BMP2 stimulated Sox9 gene expression and Sox9 promoter...

...Sabine Stöckl; Richard J. Bauer; Anja K. Bosserhoff; Claudia Göttl; Joachim Grifka; Susanne Grässel Summary Sox9 is a key transcription factor in early chondrogenesis with distinct roles in differentiation processes and during embryonic development. Here, we report that Sox9 modulates cell survival...

...Kyoko Harikae; Kento Miura; Mai Shinomura; Shogo Matoba; Ryuji Hiramatsu; Naoki Tsunekawa; Masami Kanai-Azuma; Masamichi Kurohmaru; Ken-ichirou Morohashi; Yoshiakira Kanai Summary In mammalian sex determination, SRY directly upregulates the expression of SOX9, the master regulatory transcription...

...Yoko Takigawa; Kenji Hata; Shuji Muramatsu; Katsuhiko Amano; Koichiro Ono; Makoto Wakabayashi; Akio Matsuda; Kenji Takada; Riko Nishimura; Toshiyuki Yoneda Sox9 is an essential transcription factor for chondrogenesis by regulating the expression of chondrogenic genes. However, its regulatory...

...) of intestinal epithelial cells and might have an important impact on intestinal tumorigenesis. We demonstrate here that the expression of PKCα in proliferating intestinal epithelial cells is repressed both in vitro and in vivo by the SOX9 transcription factor. This repression does not require DNA binding...

... of protein kinase B. Curr. Opin. Genet. Dev. 8 , 55 -62. Bishop, C. E., Whitworth, D. J., Qin, Y., Agoulnik, A. I., Agoulnik, I. U., Harrison, W. R., Behringer, R. R. and Overbeek, P. A. ( 2000 ). A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse...

.... The time course for expression pattern and level for cartilage specific markers, type II collagen and aggrecan, and regulators of chondrogenesis, Sox9 and IL-1β, were analyzed and compared with non-compressed control cultures. Under compressive conditions, histological evaluation showed an apparent...