...Zuriñe Antón; Virginie M. S. Betin; Boris Simonetti; Colin J. Traer; Naomi Attar; Peter J. Cullen; Jon D. Lane ABSTRACT The sorting nexins (SNXs) are a family of peripheral membrane proteins that direct protein trafficking decisions within the endocytic network. Emerging evidence in yeast...

...Chris M. Danson; Neil Pearson; Kate J. Heesom; Peter J. Cullen ABSTRACT The endo-lysosomal network serves an essential role in determining the fate of endocytosed transmembrane proteins and their associated proteins and lipids. Sorting nexins (SNXs) play a central role in the functional...

... of cargo proteins, mediated by the retromer complex. Recent work has led to significant progress in understanding the role of Arabidopsis retromer subunits in recycling vacuolar sorting receptors and plasma membrane proteins. As a consequence, members of the sorting nexin (SNX) protein family...

... synaptic function in Drosophila . In an effort to understand how Nwk carries out its dual roles, we isolated interacting proteins using mass spectrometry. We report a conserved interaction between Nwk proteins and BAR-SH3 sorting nexins, a family of membrane-binding proteins implicated in diverse...

... pathways. We previously identified sorting nexin 5 (SNX5) as a regulator of macropinocytosis in macrophages. Here, we show that bone-marrow-derived macrophages from SNX5-knockout mice had a 60–70% reduction in macropinocytic uptake of dextran or ovalbumin, whereas phagocytosis and retrograde transport from...

... 13 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 SNX14 G protein‐coupled receptor Regulator of G protein signaling Sorting nexin Guanosine triphosphatase‐activating proteins 5‐hydroxytryptamine type 6 receptor 5‐HT G‐protein‐coupled receptors (GPCRs...

...Rajesh Ghai; Maria Tello-Lafoz; Suzanne J. Norwood; Zhe Yang; Thomas Clairfeuille; Rohan D. Teasdale; Isabel Mérida; Brett M. Collins ABSTRACT Sorting nexin 27 (SNX27) controls the endosomal-to-cell-surface recycling of diverse transmembrane protein cargos. Crucial to this function...

.... , Peter   B. J. , Oorschot   V. M. , Rutherford   A. , Mellor   H. , Klumperman   J. , McMahon   H. T. , Cullen   P. J. ( 2004 ). Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.   Curr. Biol...

... by The Company of Biologists Ltd 2013 Autophagy TRAPP Golgi-associated retrograde protein Sorting nexin Retromer Atg9 Snc1 Autophagy is an evolutionarily conserved intracellular degradation system that contributes to a wide range of physiological phenomena ( Mizushima and Komatsu, 2011...

...Chris Danson; Edward Brown; Oliver J. Hemmings; Ian J. McGough; Sam Yarwood; Kate J. Heesom; Jeremy G. Carlton; Juan Martin-Serrano; Margaret T. May; Paul Verkade; Peter J. Cullen Summary Sorting nexins (SNXs) are key regulators of the endosomal network. In designing an RNAi-mediated loss...

... network is modulated by bacterial effectors, some of which, such as SigD/SopB, manipulate the level of endosomal phosphoinositides. Here, we establish that at early stages of Salmonella infection, sorting nexin-1 (SNX1) – a host phosphoinositide-binding protein that normally associates with early...

... macropinocytosis of the E-cadherin-catenin complex into endosomal compartments that colocalized with EEA1 and the sorting nexin, SNX1. Depletion of cellular SNX1 levels by siRNA resulted in increased intracellular accumulation and turnover of E-cadherin internalized from the cell surface in response to EGF...

... is composed of two subcomplexes, one containing SNX1 and forming a membrane-bound coat, the other comprising VPS26, VPS29 and VPS35 and being cargo-selective. In yeast, an additional sorting nexin - Vps17p - is a component of the membrane bound coat. It remains unclear whether the mammalian retromer requires...

...Markus C. Kerr; Margaret R. Lindsay; Robert Luetterforst; Nicholas Hamilton; Fiona Simpson; Robert G. Parton; Paul A. Gleeson; Rohan D. Teasdale We report that phosphoinositol-binding sorting nexin 5 (SNX5) associates with newly formed macropinosomes induced by EGF stimulation. We used...

...Jez G. Carlton; Miriam V. Bujny; Brian J. Peter; Viola M. J. Oorschot; Anna Rutherford; Rebecca S. Arkell; Judith Klumperman; Harvey T. McMahon; Peter J. Cullen Sorting nexins are a large family of phox-homology-domain-containing proteins that have been implicated in the control of endosomal...

.... The 5-HT 4(a) R also interacted with both the constitutive and inducible (upon methamphetamine treatment) forms of the recently cloned sorting nexin 27 (SNX27a and b, respectively). We found that SNX27a redirected part of 5-HT 4(a) R to early endosomes. The interaction of the 5-HT 4 R splice variants...

... to improve our knowledge of amphiphysin function, we performed a two-hybrid screen with the N-terminal part of murine amphiphysin 2 (residues 1-304). One of the interacting clones corresponded to sorting nexin 4 (SNX4), a member of the SNX family of proteins which are suspected to regulate vesicular...