1-17 of 17
Keywords: Sorting nexin
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Autophagy
J Cell Sci (2020) 133 (14): jcs246306.
Published: 15 July 2020
...Zuriñe Antón; Virginie M. S. Betin; Boris Simonetti; Colin J. Traer; Naomi Attar; Peter J. Cullen; Jon D. Lane ABSTRACT The sorting nexins (SNXs) are a family of peripheral membrane proteins that direct protein trafficking decisions within the endocytic network. Emerging evidence in yeast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs211672.
Published: 10 September 2018
...Chris M. Danson; Neil Pearson; Kate J. Heesom; Peter J. Cullen ABSTRACT The endo-lysosomal network serves an essential role in determining the fate of endocytosed transmembrane proteins and their associated proteins and lipids. Sorting nexins (SNXs) play a central role in the functional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs203695.
Published: 29 January 2018
... of cargo proteins, mediated by the retromer complex. Recent work has led to significant progress in understanding the role of Arabidopsis retromer subunits in recycling vacuolar sorting receptors and plasma membrane proteins. As a consequence, members of the sorting nexin (SNX) protein family...
Journal Articles
J Cell Sci (2016) 129 (1): 166–177.
Published: 1 January 2016
... synaptic function in Drosophila . In an effort to understand how Nwk carries out its dual roles, we isolated interacting proteins using mass spectrometry. We report a conserved interaction between Nwk proteins and BAR-SH3 sorting nexins, a family of membrane-binding proteins implicated in diverse...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4407–4419.
Published: 1 December 2015
... pathways. We previously identified sorting nexin 5 (SNX5) as a regulator of macropinocytosis in macrophages. Here, we show that bone-marrow-derived macrophages from SNX5-knockout mice had a 60–70% reduction in macropinocytic uptake of dextran or ovalbumin, whereas phagocytosis and retrograde transport from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (9): 1848–1861.
Published: 1 May 2015
...’ for preferential binding to 5‐HT 6 R, thus enhancing endocytic internalization and degradation of that receptor. In this study, we found that SNX14, as might be expected of a sorting nexin, accelerates internalization and degradation of 5‐HT 6 R. We also found that SNX14 specifically binds and sequesters Gαs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 553–565.
Published: 1 February 2015
...Rajesh Ghai; Maria Tello-Lafoz; Suzanne J. Norwood; Zhe Yang; Thomas Clairfeuille; Rohan D. Teasdale; Isabel Mérida; Brett M. Collins ABSTRACT Sorting nexin 27 (SNX27) controls the endosomal-to-cell-surface recycling of diverse transmembrane protein cargos. Crucial to this function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (22): 4940–4953.
Published: 15 November 2014
... Retromer Sorting nexin On arriving in the endosomal network, internalized transmembrane protein cargos have two principal fates – either they are sorted from the limiting membrane of the endosome into intraluminal vesicles for delivery to the lysosome for degradation or, alternatively...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4963–4973.
Published: 1 November 2013
... by The Company of Biologists Ltd 2013 To further understand the relationship between TRAPPIII and the other endosomal pathways, we next examined the sorting nexin complex, which functions in a retrograde pathway that is distinct from the Retromer-mediated process ( Hettema et al., 2003 ). Mutation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4885–4899.
Published: 1 November 2013
...Chris Danson; Edward Brown; Oliver J. Hemmings; Ian J. McGough; Sam Yarwood; Kate J. Heesom; Jeremy G. Carlton; Juan Martin-Serrano; Margaret T. May; Paul Verkade; Peter J. Cullen Summary Sorting nexins (SNXs) are key regulators of the endosomal network. In designing an RNAi-mediated loss...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (12): 2027–2036.
Published: 15 June 2008
... network is modulated by bacterial effectors, some of which, such as SigD/SopB, manipulate the level of endosomal phosphoinositides. Here, we establish that at early stages of Salmonella infection, sorting nexin-1 (SNX1) – a host phosphoinositide-binding protein that normally associates with early...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (10): 1818–1828.
Published: 15 May 2007
... macropinocytosis of the E-cadherin-catenin complex into endosomal compartments that colocalized with EEA1 and the sorting nexin, SNX1. Depletion of cellular SNX1 levels by siRNA resulted in increased intracellular accumulation and turnover of E-cadherin internalized from the cell surface in response to EGF...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (1): 45–54.
Published: 1 January 2007
... is composed of two subcomplexes, one containing SNX1 and forming a membrane-bound coat, the other comprising VPS26, VPS29 and VPS35 and being cargo-selective. In yeast, an additional sorting nexin - Vps17p - is a component of the membrane bound coat. It remains unclear whether the mammalian retromer requires...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (19): 3967–3980.
Published: 1 October 2006
...Markus C. Kerr; Margaret R. Lindsay; Robert Luetterforst; Nicholas Hamilton; Fiona Simpson; Robert G. Parton; Paul A. Gleeson; Rohan D. Teasdale We report that phosphoinositol-binding sorting nexin 5 (SNX5) associates with newly formed macropinosomes induced by EGF stimulation. We used...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (19): 4527–4539.
Published: 1 October 2005
...Jez G. Carlton; Miriam V. Bujny; Brian J. Peter; Viola M. J. Oorschot; Anna Rutherford; Rebecca S. Arkell; Judith Klumperman; Harvey T. McMahon; Peter J. Cullen Sorting nexins are a large family of phox-homology-domain-containing proteins that have been implicated in the control of endosomal...
Journal Articles
J Cell Sci (2004) 117 (22): 5367–5379.
Published: 15 October 2004
.... The 5-HT 4(a) R also interacted with both the constitutive and inducible (upon methamphetamine treatment) forms of the recently cloned sorting nexin 27 (SNX27a and b, respectively). We found that SNX27a redirected part of 5-HT 4(a) R to early endosomes. The interaction of the 5-HT 4 R splice variants...
Journal Articles
J Cell Sci (2003) 116 (10): 1937–1948.
Published: 15 May 2003
... to improve our knowledge of amphiphysin function, we performed a two-hybrid screen with the N-terminal part of murine amphiphysin 2 (residues 1-304). One of the interacting clones corresponded to sorting nexin 4 (SNX4), a member of the SNX family of proteins which are suspected to regulate vesicular...