... motifs. Fig. 8. The dileucine mutant Cx32-LI is endocytosed via the LL and LR motifs. (A) A schematic diagram showing the location of the amino acids mutated in the sorting motifs of Cx32 (see also Fig. 2 ). In the mutant LI-LL, only the LR motif (green) is functional. In mutant LI-LR, only...

.... However, the significance of Atg9A trafficking for autophagosome formation remains elusive. Here, we identified sorting motifs in the N-terminal cytosolic stretch of Atg9A that interact with the adaptor protein AP-2. Atg9A with mutations in the sorting motifs could not execute autophagy and was abnormally...

... residues flanking the PRD are crucial to the sorting motif and changing the charge of these residues causes mis-sorting to the plasma membrane. In cells with conventional lysosomes, this motif is not recognised and FasL is expressed at the plasma membrane. The FasL PRD is not required for endocytosis...