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Keywords: Snail
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Adhesion
J Cell Sci (2020) 133 (13): jcs235622.
Published: 06 July 2020
... ranging from apoptosis to oncogenic transformation. To explore whether the morphogenetic transcription factor Snail (SNAI1) induces extrusion, we inducibly expressed a stabilized Snail 6SA transgene in confluent MCF-7 monolayers. When expressed in small clusters (less than three cells) within otherwise...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4231–4239.
Published: 15 December 2010
... is downregulation of the adherens junction protein E-cadherin, a process mediated by transcription factors such as the zinc fingers SNAIL and SLUG. Here, we report that the catalytic IκB kinase (IKK) subunit IKKα is necessary for the silencing of E-cadherin in a Panc1 cell model of TGFβ–SMAD-mediated EMT...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4321–4331.
Published: 15 December 2010
.... , Alameda F. , Gómez S. , Rodríguez R. , Escrivà M. , Montserrat-Sentís B. , Baró T. , Garrido M. , et al . ( 2006 ) Expression of Snail protein in tumor-stroma interface . Oncogene . 37 , 5134 - 5144 . urlong E. E. , Andersen E. C. , Null B...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (9): 1452–1460.
Published: 01 May 2009
...José-Manuel Mingot; Sonia Vega; Beatriz Maestro; Jesús M. Sanz; M. Angela Nieto Snail proteins are C 2 H 2 class zinc finger transcription factors involved in different processes during embryonic development, as well as in several adult pathologies including cancer and organ fibrosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 1014–1024.
Published: 01 April 2009
... ). The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2 , 84 -89. Bayly, R., Chuen, L., Currie, R. A., Hyndman, B. D., Casselman, R., Blobel, G. A. and LeBrun, D. P. ( 2004 ). E2A-PBX1 interacts directly with the KIX domain of CBP/p300...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (20): 3317–3324.
Published: 15 October 2008
... α-actin, SM22α and calponin, whereas a TGFβ type I receptor kinase inhibitor inhibited EndMT. Among the transcription factors involved in EMT, Snail was induced by TGFβ2 in MESECs. Tetracycline-regulated expression of Snail induced the differentiation of MESECs into mural cells, whereas knockdown...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (13): 2224–2234.
Published: 01 July 2008
... significant expression of LEF1 (data not shown). Therefore, these results indicate that the expression of mesenchymal genes is under the control of β-catenin through TCF4-dependent or -independent complexes. Cadherin EMT NF-κB Snail β-catenin Epithelial cells have a high degree...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (15): 3371–3385.
Published: 01 August 2005
...Mireia Jordà; David Olmeda; Antònia Vinyals; Eva Valero; Eva Cubillo; Ana Llorens; Amparo Cano; Àngels Fabra Overexpression of the transcription factor Snail in epithelial MDCK cells promotes the epithelial-mesenchymal transition (EMT) and the acquisition of an invasive phenotype. We report here...
Journal Articles
J Cell Sci (2004) 117 (13): 2827–2839.
Published: 01 June 2004
...Hector Peinado; Faustino Marin; Eva Cubillo; Hans-Juergen Stark; Norbert Fusenig; M. Angela Nieto; Amparo Cano The transcription factors Snail and E47 are direct repressors of E-cadherin , with both inducing a full epithelial-mesenchymal transition and invasive behaviour in vitro when expressed...
Journal Articles
J Cell Sci (2004) 117 (9): 1675–1685.
Published: 01 April 2004
...Tadashi Ohkubo; Masayuki Ozawa Snail, a transcriptional repressor of E-cadherin expression, is involved in epithelial-mesenchymal transitions during development. We demonstrate that Snail activity is not restricted to E-cadherin downregulation. Expression of tight junction proteins, including...
Journal Articles
J Cell Sci (2003) 116 (10): 1959–1967.
Published: 15 May 2003
...Junichi Ikenouchi; Miho Matsuda; Mikio Furuse; Shoichiro Tsukita Snail is a transcription repressor that plays a central role in the epithelium-mesenchyme transition (EMT), by which epithelial cells lose their polarity. Claudins and occludin are integral membrane proteins localized at tight...