... ranging from apoptosis to oncogenic transformation. To explore whether the morphogenetic transcription factor Snail (SNAI1) induces extrusion, we inducibly expressed a stabilized Snail 6SA transgene in confluent MCF-7 monolayers. When expressed in small clusters (less than three cells) within otherwise...

... is downregulation of the adherens junction protein E-cadherin, a process mediated by transcription factors such as the zinc fingers SNAIL and SLUG. Here, we report that the catalytic IκB kinase (IKK) subunit IKKα is necessary for the silencing of E-cadherin in a Panc1 cell model of TGFβ–SMAD-mediated EMT...

... downregulation, such as zinc finger proteins of Snail, ZEB and bHLH families ( Peinado et al., 2007 ). We found that p38 inhibition limited the expression of Snail1, a factor that is rapidly induced by T/I treatment and plays a major role in the induction of EMT in MCs ( Strippoli et al., 2008...

...José-Manuel Mingot; Sonia Vega; Beatriz Maestro; Jesús M. Sanz; M. Angela Nieto Snail proteins are C 2 H 2 class zinc finger transcription factors involved in different processes during embryonic development, as well as in several adult pathologies including cancer and organ fibrosis...

... ). The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2 , 84 -89. Bayly, R., Chuen, L., Currie, R. A., Hyndman, B. D., Casselman, R., Blobel, G. A. and LeBrun, D. P. ( 2004 ). E2A-PBX1 interacts directly with the KIX domain of CBP/p300...

... α-actin, SM22α and calponin, whereas a TGFβ type I receptor kinase inhibitor inhibited EndMT. Among the transcription factors involved in EMT, Snail was induced by TGFβ2 in MESECs. Tetracycline-regulated expression of Snail induced the differentiation of MESECs into mural cells, whereas knockdown...

... The Company of Biologists Limited 2008 2008 Cadherin EMT NF-κB Snail β-catenin Epithelial cells have a high degree of plasticity: they can convert to a mesenchymal phenotype in a process known as epithelial-to-mesenchymal transition (EMT) ( Savagner, 2001 ; Huber et al., 2005...

...Mireia Jordà; David Olmeda; Antònia Vinyals; Eva Valero; Eva Cubillo; Ana Llorens; Amparo Cano; Àngels Fabra Overexpression of the transcription factor Snail in epithelial MDCK cells promotes the epithelial-mesenchymal transition (EMT) and the acquisition of an invasive phenotype. We report here...

...Hector Peinado; Faustino Marin; Eva Cubillo; Hans-Juergen Stark; Norbert Fusenig; M. Angela Nieto; Amparo Cano The transcription factors Snail and E47 are direct repressors of E-cadherin , with both inducing a full epithelial-mesenchymal transition and invasive behaviour in vitro when expressed...

...Tadashi Ohkubo; Masayuki Ozawa Snail, a transcriptional repressor of E-cadherin expression, is involved in epithelial-mesenchymal transitions during development. We demonstrate that Snail activity is not restricted to E-cadherin downregulation. Expression of tight junction proteins, including...

...Junichi Ikenouchi; Miho Matsuda; Mikio Furuse; Shoichiro Tsukita Snail is a transcription repressor that plays a central role in the epithelium-mesenchyme transition (EMT), by which epithelial cells lose their polarity. Claudins and occludin are integral membrane proteins localized at tight...

... with down-regulation of expression of HNF4 and HNF1α and activation of Snail transcripts. The effects of TGFβ were dominant if it was added with FGF1, but the effects on differentiation were abrogated if cells had been pre-treated with FGF1. This work identifies TGFβ as a factor that could be implicated...