...Cristina Moreno-Castro; Silvia Prieto-Sánchez; Noemí Sánchez-Hernández; Cristina Hernández-Munain; Carlos Suñé ABSTRACT Cajal bodies are nuclear organelles involved in the nuclear phase of small nuclear ribonucleoprotein (snRNP) biogenesis. In this study, we identified the splicing factor TCERG1...

...Alan R. Prescott; Alexandra Bales; John James; Laura Trinkle-Mulcahy; Judith E. Sleeman ABSTRACT The biogenesis of splicing snRNPs (small nuclear ribonucleoproteins) is a complex process, beginning and ending in the nucleus of the cell but including key stages that take place in the cytoplasm...

... (SMN) protein. SMN is required for the biogenesis of small nuclear ribonucleoproteins (snRNPs): essential components of the spliceosome. Splicing abnormalities have been detected in models of SMA but it is unclear how lowered SMN affects the fidelity of pre-mRNA splicing. We have examined the dynamics...

... and photoactivatable GFP, I have demonstrated that pathways with uni-directional bulk flow of complexes can be maintained within the nucleus despite multi-directional exchange of individual complexes. Newly imported splicing small nuclear ribonucleoproteins (snRNPs) exchange between Cajal bodies (CBs) within a nucleus...

... ribonucleoproteins (snRNPs). The protein is detected in the cytoplasm, nucleoplasm and enriched with snRNPs in nuclear Cajal bodies. It is structurally divided into at least an amino-terminal region rich in basic amino acid residues, a central Tudor domain, a self-association tyrosine-glycine-box and an exon7...

... of Biologists Limited 2005 2005 PIASy SUMO snRNPs U snRNA gene loci Nuclear organization The nucleus in eukaryotes is highly organized and contains numerous territories, domains and bodies ( Lamond and Earnshaw, 1998 ; Spector, 2001 ; Zimber et al., 2004 ). The Cajal body and PML body...

...Judith E. Sleeman; Paul Ajuh; Angus I. Lamond Splicing snRNPs (small nuclear ribonucleoproteins) are essential sub-units of the spliceosome. Here we report the establishment of stable cell lines expressing fluorescently tagged SmB, a core snRNP protein. Analysis of these stable cell lines has...

...Demetrios J. Sahlas; Kosta Milankov; Paul C. Park; Umberto De Boni ABSTRACT Small nuclear ribonucleoproteins (snRNPs) play an integral role in the processing of pre-mRNA in eukaryotic nuclei. snRNPs often occur in a speckled intranuclear distribution, together with the non-snRNP splicing factor SC...