...Shuang Li; Yong Suk Cho; Bing Wang; Shuangxi Li; Jin Jiang ABSTRACT Hedgehog (Hh) transduces signals by promoting cell surface accumulation and activation of the G-protein-coupled receptor (GPCR)-family protein Smoothened (Smo) in Drosophila , but the molecular mechanism underlying the regulation...

...Kai Jiang; Yajuan Liu; Jie Zhang; Jianhang Jia ABSTRACT Smoothened (Smo), a GPCR family protein, plays a critical role in the reception and transduction of Hedgehog (Hh) signal. Smo is phosphorylated and activated on the cell surface; however, it is unknown whether Smo can be intracellularly...