..., Rab37) are predominantly targeted to dense-core vesicles in PC12 cells, and that three of them (Rab3A, Rab27A, Rab33A) are endogenously expressed on dense-core vesicles. We further investigated the effect of silencing each Rab with specific small interfering RNA on vesicle dynamics by total internal...

... of CPX I occurs in a dose-dependent manner. The figure shows the mean ± s.e.m. of at least three independent experiments measured in triplicate (* P<0.01, ***P<0.001). Fig. 4. CPX I expression is efficiently silenced by plasmids directing the synthesis of small interfering RNAs (siRNA...

... NudC levels by either small interfering RNA-mediated gene silencing or adenovirus-mediated overexpression resulted in multinucleated cells and cells with persistent intercellular connections and disorganized midzone and midbody matrix. These phenotypes suggest a failure in cytokinesis in NudC altered...