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Keywords: Small GTPase
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Journal Articles
J Cell Sci (2023) 136 (15): jcs261319.
Published: 9 August 2023
... to destinations; however, the sorting mechanism remains largely unknown. Here, we show that ARF6 plays a general role in targeting palmitoylated proteins from the Golgi to the plasma membrane (PM). Through shRNA screening, we identified ARF6 as the key small GTPase in targeting CD36, a palmitoylated protein, from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (24): jcs259184.
Published: 17 December 2021
...Yuki Hatoyama; Yuta Homma; Shu Hiragi; Mitsunori Fukuda ABSTRACT Two small GTPases, Rab1 and Rab5, are key membrane trafficking regulators that are conserved in all eukaryotes. They have recently been found to be essential for cell survival and/or growth in cultured mammalian cells, thereby...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs235531.
Published: 1 November 2019
... to the F2 domain for its recruitment to adhesion sites to trigger integrin activation. Integrin Small GTPase Rap1 Talin RIAM NMR Integrins are heterodimeric transmembrane receptors that mediate strong adhesion of cells to the extracellular matrix or other cells by connecting...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2018) 131 (9): jcs212324.
Published: 4 May 2018
... binds tubulin to maintain uniform distribution of proteins along the ciliary membrane. Primary cilia Arl13b Ciliopathies Joubert syndrome Ciliary membrane Small GTPase Tubulin Axoneme Primary cilia are elongated protrusions of the cellular membrane where components of multiple...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (18): 3158–3172.
Published: 15 September 2017
...Hironori Inaba; Koji Yoda; Hiroyuki Adachi ABSTRACT Macropinocytosis involves the uptake of large volumes of fluid, which is regulated by various small GTPases. The Dictyostelium discoideum protein GflB is a guanine nucleotide exchange factor (GEF) of Rap1, and is involved in chemotaxis. Here, we...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (17): 2893–2902.
Published: 1 September 2017
...Hirohiko Iwasaki; Tomohiro Yorimitsu; Ken Sato ABSTRACT The COPII coat and the small GTPase Sar1 mediate protein export from the endoplasmic reticulum (ER) via specialized domains known as the ER exit sites. The peripheral ER protein Sec16 has been proposed to organize ER exit sites. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 541–550.
Published: 1 February 2017
..., such as granule recruitment to the fusion site, whereas Rab2a functions in the early steps, such as granule biogenesis and maturation. Here, we demonstrate that these two small GTPases simultaneously bind to Noc2 (also known as RPH3AL) in a GTP-dependent manner, although Rab2a binds only after Rab27a has bound...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (2): 329–340.
Published: 15 January 2016
... Highlighted Article: A combination of a Rab7 sensor and confocal FRET imaging techniques revealed that the Mon1–Ccz1 complex activates Rab7 only on late endosome and dissociates from lysosome in mammalian cells. Small GTPase FRET Endolysosomal pathway GEF Endocytosis and endolysosomal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2589–2600.
Published: 1 June 2014
... subfamily of small GTPases. The guanine-nucleotide-exchange factor (GEF) P-Rex1 is engaged downstream of GPCRs and phosphoinositide 3-kinase (PI3K) in many cell types, and promotes tumorigenic signalling and metastasis in breast cancer and melanoma, respectively. Although P-Rex1-dependent functions have...
Journal Articles
J Cell Sci (2012) 125 (21): 5177–5187.
Published: 1 November 2012
... of the actin-dependent melanosome transport and the mechanism of the microtubule-dependent retrograde melanosome transport in mammalian skin melanocytes have already been determined, almost nothing is known about the mechanism of the microtubule-dependent anterograde melanosome transport. Small GTPase Rab...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4435–4444.
Published: 1 October 2012
...Ivan de Curtis; Jacopo Meldolesi Summary Small GTPases are known to regulate hundreds of cell functions. In particular, Rho family GTPases are master regulators of the cytoskeleton. By regulating actin nucleation complexes, Rho GTPases control changes in cell shape, including the extension...
Journal Articles
J Cell Sci (2011) 124 (9): 1373–1382.
Published: 1 May 2011
... in vertebrates. * Authors for correspondence ( marie-odile.fauvarque@cea.fr ; m.j.williams@abdn.ac.uk ) © 2011. 2011 Cellular immunity Haemocyte Integrin Phagocytosis Parasitisation Small GTPase Ever since Boman et al. ( Boman et al., 1972 ) published their seminal paper showing...
Journal Articles
J Cell Sci (2009) 122 (22): 4228–4238.
Published: 15 November 2009
... and cell migration. Crk-dependent signaling is crucial during the early stages of PDGFβR activation, whereas its termination by Abl family tyrosine kinases is important for turnover of focal adhesions and progression of dorsal-membrane ruffles. CrkII and CrkL preferentially activate the small GTPase Rac1...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (2): 143–148.
Published: 15 January 2008
... separation resulting in the formation of large clusters of cells that are connected by their primary septum ( Sandrock et al., 2006 ; Weinzierl et al., 2002 ). Cell division Ustilago maydis Germinal centre kinase Chemical genetics Small GTPase © The Company of Biologists Limited 2008...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2002) 115 (24): 4915–4924.
Published: 15 December 2002
.../HEF1 association domain also shows sequence similarity with guanine nucleotide exchange factors for Ras family small GTPases. In this study, we found significant activation of Rap1 in Chat-overexpressing cells. Myr-Chat, a membrane-targeted form of Chat,activated Rap1 more efficiently. Interestingly...
Journal Articles
J Cell Sci (2002) 115 (10): 2119–2129.
Published: 15 May 2002
... morphogenesis. We previously implicated the small GTPase Drac1 in the assembly of an actomyosin contractile apparatus, contributing to cell shape change in the epidermis during dorsal closure. We now present evidence that Drac1 and Crumbs, a determinant of epithelial polarity, are involved in setting up...