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Keywords: Smad7
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Journal Articles
J Cell Sci (2022) 135 (1): jcs259097.
Published: 12 January 2022
... with transforming growth factor-β (TGF-β)–Smad and Wnt/β-catenin pathways. Previously, we implicated Smad7 and β-catenin in mammalian myogenesis. Therefore, we assessed a potential role of TAZ on the Smad7–β-catenin complex in muscle cells. Here, we document functional interactions between Smad7, TAZ and β-catenin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (2): 411–421.
Published: 15 January 2014
... in numerous tissues and organs. Thus, targeting Myc stability could be a crucial step for cancer therapy. Here we report Smad7 as a key molecule regulating Myc stability and activity by recruiting the F-box protein, Skp2. Ectopic expression of Smad7 downregulated the protein level of Myc without affecting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (9): 1835–1847.
Published: 1 April 2004
.... The inhibitory Smads, Smad6 and Smad7, are considered to function as negative regulators of the TGF-β/Smad signaling cascade. In a previous study, we found that TGF-β induces rearrangements of the actin filament system in human prostate carcinoma cells and that this response requires the small GTPases Cdc42...