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1-20 of 25
Keywords: Skin
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (12): jcs261899.
Published: 28 June 2024
... to dynamically counter the contractile forces generated by actin-associated adherens junctions is particularly important in tissues under high mechanical stress, such as the skin and heart. Much more than the simple cellular ‘spot welds’ depicted in textbooks, desmosomes are in fact dynamic structures that can...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (23): jcs249102.
Published: 7 December 2020
... spatial cues. Owing to the lack of an appropriate model system that can recapitulate the architecture of the skin, deregulation of spindle orientation in human epithelial carcinoma has never been investigated. Here, using an inducible model of human squamous cell carcinoma (SCC), we demonstrate that RAS...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (21): 3997–4013.
Published: 1 November 2015
... performed a multiplexed small hairpin (sh)RNA screen to define roles for each subunit in human organotypic skin. We show that integrin-αv (also known as ITGAV) heterodimers are essential for epidermal generation, with integrin-αv loss driving a keratinocyte G1–S cell cycle block. Surprisingly, integrin αv...
Includes: Supplementary data
Journal Articles
Esra Karaköse, Tamar Geiger, Kevin Flynn, Katrin Lorenz-Baath, Roy Zent, Matthias Mann, Reinhard Fässler
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (5): 1023–1033.
Published: 1 March 2015
... ( [email protected] ) Competing interests The authors declare no competing or financial interests. 1 09 2014 2 01 2015 © 2015. Published by The Company of Biologists Ltd 2015 Integrin Focal adhesion EPLIN LIMA1 PINCH-1 LIMS1 Keratinocyte Skin The skin...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (20): 4602–4613.
Published: 15 October 2013
..., was not included in our analysis but is thought to be expressed in zebrafish skin according to aberrant cell extrusion function within the epithelium of Piezo1-knockdown animals ( Eisenhoffer et al., 2012 ). The keratinocyte expression profile reflects not only basal keratinocytes ( tp63 , Bakkers et al., 2002...
Includes: Supplementary data
Journal Articles
Hamid Reza Rezvani, Nsrein Ali, Martin Serrano-Sanchez, Pierre Dubus, Christine Varon, Cécile Ged, Catherine Pain, Muriel Cario-André, Julien Seneschal, Alain Taïeb, Hubert de Verneuil, Frédéric Mazurier
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (24): 4172–4183.
Published: 15 December 2011
...Hamid Reza Rezvani; Nsrein Ali; Martin Serrano-Sanchez; Pierre Dubus; Christine Varon; Cécile Ged; Catherine Pain; Muriel Cario-André; Julien Seneschal; Alain Taïeb; Hubert de Verneuil; Frédéric Mazurier In mouse and human skin, HIF-1α is constitutively expressed in the epidermis, mainly...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (24): 4221–4232.
Published: 15 December 2011
... 2011 © 2011. 2011 Keratins Amino acids Skin Glandular epithelium The cytoskeleton of eukaryotic cells consists of three filamentous arrays – the microtubules, the actin-containing microfilaments and the intermediate filaments (IFs) ( Ku et al., 1999 ; Alberts et al., 2008 ). IFs...
Includes: Supplementary data
Journal Articles
Mohammed I. Ahmed, Andrei N. Mardaryev, Christopher J. Lewis, Andrey A. Sharov, Natalia V. Botchkareva
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (20): 3399–3404.
Published: 15 October 2011
...Mohammed I. Ahmed; Andrei N. Mardaryev; Christopher J. Lewis; Andrey A. Sharov; Natalia V. Botchkareva Bone morphogenetic proteins (BMPs) play essential roles in the control of skin development, postnatal tissue remodelling and tumorigenesis. To explore whether some of the effects of BMP signalling...
Includes: Supplementary data
Journal Articles
Gareth Browne, Rita Cipollone, Anna Maria Lena, Valeria Serra, Huiqing Zhou, Hans van Bokhoven, Volker Dötsch, Daniele Merico, Roberto Mantovani, Alessandro Terrinoni, Richard A. Knight, Eleonora Candi, Gerry Melino
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (13): 2200–2207.
Published: 1 July 2011
...-binding and sterile alpha motif (SAM) domain mutants accumulate in the skin of EEC and AEC syndrome patients, respectively, and show extended half lives in vitro. By contrast, C-terminal mutations found in SHFM patients have half-lives similar to that of the wild-type protein. The increased half-life...
Includes: Supplementary data
Journal Articles
Katrin Blumbach, Manon C. Zweers, Georg Brunner, Andreas S. Peters, Markus Schmitz, Jan-Niklas Schulz, Alexander Schild, Christopher P. Denton, Takao Sakai, Reinhard Fässler, Thomas Krieg, Beate Eckes
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (22): 3872–3883.
Published: 15 November 2010
... and dysregulated cell proliferation, which is either augmented or repressed, depending on the affected cell type. We targeted ILK inactivation to fibroblasts in the skin of young mice to test the hypothesis that ILK maintains a crucial function as a docking structure in FAs connecting the ECM with the actin...
Includes: Supplementary data
Journal Articles
Wonseon Choi, Rainer Wolber, Wolfram Gerwat, Tobias Mann, Jan Batzer, Christoph Smuda, Hongfang Liu, Ludger Kolbe, Vincent J. Hearing
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (18): 3102–3111.
Published: 15 September 2010
...Wonseon Choi; Rainer Wolber; Wolfram Gerwat; Tobias Mann; Jan Batzer; Christoph Smuda; Hongfang Liu; Ludger Kolbe; Vincent J. Hearing Interactions between melanocytes and neighboring cells in the skin are important in regulating skin color in humans. We recently demonstrated that the less pigmented...
Includes: Supplementary data
Journal Articles
Vera L. Martins, Jashmin J. Vyas, Mei Chen, Karin Purdie, Charles A. Mein, Andrew P. South, Alan Storey, John A. McGrath, Edel A. O'Toole
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (11): 1788–1799.
Published: 1 June 2009
... that are responsible for attachment of the epidermis to the dermis in skin. Mutations in the human ColVII gene, COL7A1 , cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae, associated with a greatly increased risk of skin cancer. In this study...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (10): 1758–1769.
Published: 15 May 2008
...Denggao Yao; Claire L. Alexander; Jean A. Quinn; Weng-Chyn Chan; Hong Wu; David A. Greenhalgh To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate Pten function ( K14.cre/ Δ 5Pten flx ) in mouse epidermis expressing activated Fos...
Includes: Supplementary data
Journal Articles
Eleonora Candi, Alessandro Terrinoni, Alessandro Rufini, Anissa Chikh, Anna Maria Lena, Yasuhiro Suzuki, Berna S. Sayan, Richard A. Knight, Gerry Melino
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (22): 4617–4622.
Published: 15 November 2006
...Eleonora Candi; Alessandro Terrinoni; Alessandro Rufini; Anissa Chikh; Anna Maria Lena; Yasuhiro Suzuki; Berna S. Sayan; Richard A. Knight; Gerry Melino The epidermis, the outer layer of the skin composed of keratinocytes, develops following the action of the transcription factor p63. The mouse...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (19): 4033–4046.
Published: 1 October 2006
...Sandra Pankow; Casimir Bamberger; Anke Klippel; Sabine Werner The epidermis undergoes continuous self-renewal to maintain its protective function. Whereas growth factors are known to modulate overall skin homeostasis, the intracellular signaling pathways, which control the delicate balance between...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (3): 592–602.
Published: 1 February 2006
...Christine E. Pullar; R. Rivkah Isseroff Dermal fibroblasts are required for skin wound repair; they migrate into the wound bed, proliferate, synthesize extracellular matrix components and contract the wound. Although fibroblasts express β2-adrenergic receptors (β2-AR) and cutaneous keratinocytes...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (9): 1981–1989.
Published: 1 May 2005
...Lore Florin; Nicole Maas-Szabowski; Sabine Werner; Axel Szabowski; Peter Angel In skin, fibroblasts of the connective tissue play a decisive role in epidermal homeostasis and repair by contributing to the regulation of keratinocyte proliferation and differentiation. The AP-1 transcription factor...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (5): 667–675.
Published: 15 February 2004
...J. Michael Sorrell; Arnold I. Caplan Dermal fibroblasts are a dynamic and diverse population of cells whose functions in skin in many respects remain unknown. Normal adult human skin contains at least three distinct subpopulations of fibroblasts, which occupy unique niches in the dermis...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (18): 3783–3791.
Published: 15 September 2003
... Mammalian Genetics Unit, Harwell OX11 ORD, UK 24 6 2003 © The Company of Biologists Limited 2003 2003 Keratinocyte Differentiation Carcinogenesis Skin Smad The epidermis is a constantly renewing tissue that is maintained by a highly coordinated balance between keratinocyte...
Journal Articles
Andrew P. South, Hong Wan, Michael G. Stone, Patricia J. C. Dopping-Hepenstal, Patricia E. Purkis, John F. Marshall, Irene M. Leigh, Robin A. J. Eady, Ian R. Hart, John A. McGrath
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (16): 3303–3314.
Published: 15 August 2003
...Andrew P. South; Hong Wan; Michael G. Stone; Patricia J. C. Dopping-Hepenstal; Patricia E. Purkis; John F. Marshall; Irene M. Leigh; Robin A. J. Eady; Ian R. Hart; John A. McGrath Ablation of the desmosomal plaque component plakophilin 1 underlies the autosomal recessive genodermatosis, skin...
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