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Keywords: Skin
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Journal Articles
J Cell Sci (2020) 133 (23): jcs249102.
Published: 7 December 2020
... spatial cues. Owing to the lack of an appropriate model system that can recapitulate the architecture of the skin, deregulation of spindle orientation in human epithelial carcinoma has never been investigated. Here, using an inducible model of human squamous cell carcinoma (SCC), we demonstrate that RAS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3997–4013.
Published: 1 November 2015
... performed a multiplexed small hairpin (sh)RNA screen to define roles for each subunit in human organotypic skin. We show that integrin-αv (also known as ITGAV) heterodimers are essential for epidermal generation, with integrin-αv loss driving a keratinocyte G1–S cell cycle block. Surprisingly, integrin αv...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 1023–1033.
Published: 1 March 2015
... ( faessler@biochem.mpg.de ) Competing interests The authors declare no competing or financial interests. 1 09 2014 2 01 2015 © 2015. Published by The Company of Biologists Ltd 2015 Integrin Focal adhesion EPLIN LIMA1 PINCH-1 LIMS1 Keratinocyte Skin The skin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4602–4613.
Published: 15 October 2013
..., was not included in our analysis but is thought to be expressed in zebrafish skin according to aberrant cell extrusion function within the epithelium of Piezo1-knockdown animals ( Eisenhoffer et al., 2012 ). The keratinocyte expression profile reflects not only basal keratinocytes ( tp63 , Bakkers et al., 2002...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (24): 4221–4232.
Published: 15 December 2011
... 2011 © 2011. 2011 Keratins Amino acids Skin Glandular epithelium The cytoskeleton of eukaryotic cells consists of three filamentous arrays – the microtubules, the actin-containing microfilaments and the intermediate filaments (IFs) ( Ku et al., 1999 ; Alberts et al., 2008 ). IFs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (20): 3399–3404.
Published: 15 October 2011
...Mohammed I. Ahmed; Andrei N. Mardaryev; Christopher J. Lewis; Andrey A. Sharov; Natalia V. Botchkareva Bone morphogenetic proteins (BMPs) play essential roles in the control of skin development, postnatal tissue remodelling and tumorigenesis. To explore whether some of the effects of BMP signalling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2200–2207.
Published: 1 July 2011
...-binding and sterile alpha motif (SAM) domain mutants accumulate in the skin of EEC and AEC syndrome patients, respectively, and show extended half lives in vitro. By contrast, C-terminal mutations found in SHFM patients have half-lives similar to that of the wild-type protein. The increased half-life...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (11): 1788–1799.
Published: 1 June 2009
... that are responsible for attachment of the epidermis to the dermis in skin. Mutations in the human ColVII gene, COL7A1 , cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae, associated with a greatly increased risk of skin cancer. In this study...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2006) 119 (22): 4617–4622.
Published: 15 November 2006
...Eleonora Candi; Alessandro Terrinoni; Alessandro Rufini; Anissa Chikh; Anna Maria Lena; Yasuhiro Suzuki; Berna S. Sayan; Richard A. Knight; Gerry Melino The epidermis, the outer layer of the skin composed of keratinocytes, develops following the action of the transcription factor p63. The mouse...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (19): 4033–4046.
Published: 1 October 2006
...Sandra Pankow; Casimir Bamberger; Anke Klippel; Sabine Werner The epidermis undergoes continuous self-renewal to maintain its protective function. Whereas growth factors are known to modulate overall skin homeostasis, the intracellular signaling pathways, which control the delicate balance between...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (3): 592–602.
Published: 1 February 2006
...Christine E. Pullar; R. Rivkah Isseroff Dermal fibroblasts are required for skin wound repair; they migrate into the wound bed, proliferate, synthesize extracellular matrix components and contract the wound. Although fibroblasts express β2-adrenergic receptors (β2-AR) and cutaneous keratinocytes...
Journal Articles
J Cell Sci (2005) 118 (9): 1981–1989.
Published: 1 May 2005
...Lore Florin; Nicole Maas-Szabowski; Sabine Werner; Axel Szabowski; Peter Angel In skin, fibroblasts of the connective tissue play a decisive role in epidermal homeostasis and repair by contributing to the regulation of keratinocyte proliferation and differentiation. The AP-1 transcription factor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (5): 667–675.
Published: 15 February 2004
...J. Michael Sorrell; Arnold I. Caplan Dermal fibroblasts are a dynamic and diverse population of cells whose functions in skin in many respects remain unknown. Normal adult human skin contains at least three distinct subpopulations of fibroblasts, which occupy unique niches in the dermis...
Journal Articles
J Cell Sci (2003) 116 (18): 3783–3791.
Published: 15 September 2003
.... A., Myers, T. E. and Wang, X. J. ( 2001 ). Smads mediate signaling of the TGFβ superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis. Oncogene 20 , 471 -483. Hodivala, K. J. and Watt, F. M. ( 1994 ). Evidence that cadherins play a role in the down regulation...
Journal Articles
J Cell Sci (2003) 116 (16): 3303–3314.
Published: 15 August 2003
...Andrew P. South; Hong Wan; Michael G. Stone; Patricia J. C. Dopping-Hepenstal; Patricia E. Purkis; John F. Marshall; Irene M. Leigh; Robin A. J. Eady; Ian R. Hart; John A. McGrath Ablation of the desmosomal plaque component plakophilin 1 underlies the autosomal recessive genodermatosis, skin...
Journal Articles
J Cell Sci (2001) 114 (1): 131–139.
Published: 1 January 2001
... phenomena. TNF-α stimulates secretion of active MMP-2, a type IV collagenase, in organ-cultured full-thickness human skin. This suggests a mechanism whereby excess inflammation affects normal wound healing. To investigate this observation at the cellular and molecular levels, we examined TNF-α mediated...