... generated Ccndbp1-knockout (KO) mice by using CRISPR–Cas9 and found that the cross sectional area of the tibialis anterior muscle in Ccndbp1-KO mice was smaller than that in wild-type (WT) mice. The skeletal muscle regeneration efficiency of Ccndbp1-KO mice was impaired significantly compared to that in WT...

...Juan Carlos Casar; Claudio Cabello-Verrugio; Hugo Olguin; Rebeca Aldunate; Nibaldo C. Inestrosa; Enrique Brandan Skeletal muscle regeneration is a highly complex and regulated process that involves muscle precursor proliferation and differentiation and probably requires the participation of heparin...

...-sulfate-dependent mechanism. These results indicate that histone H1 is present in the extracellular matrix of skeletal muscle cells, where it interacts specifically with perlecan and exerts a strong proliferative effect on myoblasts, suggesting a role for histone H1 during skeletal muscle regeneration...