..., a pivotal extracellular regulator of muscle homeostasis, counteracts myogenic differentiation and sustains stemness by modulating intracellular signals involved in myogenesis. Extracellular matrix Skeletal muscle Muscle stem cells Collagen VI Ministero dell'Università e della Ricerca http...

... (inset in J‴). Values are expressed as mean±s.e.m. P -values shown were calculated with a two-tailed, unpaired t -test. Since TLE family proteins play essential roles in cell fate specification and differentiation, we explored whether TLEs are expressed in the skeletal muscle. We found that TLE4...

... in skeletal muscle. Sarcoplasmic reticulum Excitation-contraction coupling KEKE Skeletal muscle Triads Fondazione Telethon http://dx.doi.org/10.13039/501100002426 GGP19291 Ministry of Education, University and Research http://dx.doi.org/10.13039/501100003407 2015ZZR4W3...

...Helena Pinheiro; Mafalda Ramos Pimentel; Catarina Sequeira; Luís Manuel Oliveira; Anna Pezzarossa; William Roman; Edgar R. Gomes ABSTRACT Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences...

... muscle phenotype and to play a key role in muscle sexual dimorphisms. Skeletal muscle is a highly organized contractile tissue that comprises 40% of human body mass ( Janssen et al., 2000 ). Muscle subgroups are further specialized to perform a diverse array of functions, such as chewing, focusing...

...Osvaldo Contreras; Meilyn Cruz-Soca; Marine Theret; Hesham Soliman; Lin Wei Tung; Elena Groppa; Fabio M. Rossi; Enrique Brandan ABSTRACT Fibro–adipogenic progenitors (FAPs) are tissue-resident mesenchymal stromal cells (MSCs) required for proper skeletal muscle development, regeneration...

.... Zammit; Henning Wackerhage ABSTRACT VGLL proteins are transcriptional co-factors that bind TEAD family transcription factors to regulate events ranging from wing development in fly, to muscle fibre composition and immune function in mice. Here, we characterise Vgll3 in skeletal muscle. We found...

... aging, immunodeficiency, cancer predisposition, growth retardation and motor defects, but not cerebellar neurodegeneration and ataxia. We explored whether Atm loss is responsible for skeletal muscle defects by investigating myofiber morphology, oxidative/glycolytic activity, myocyte ultrastructural...

... Article: Exercise and electrical stimulation increase the frequency of elongated mitochondrial constrictions, providing novel structural evidence for mitochondrial dynamics stages in mouse fast-twitch muscle fibers. Fatigue Fission Mitochondria Skeletal muscle National Institute...

...Paul Knopp; Yvonne D. Krom; Christopher R. S. Banerji; Maryna Panamarova; Louise A. Moyle; Bianca den Hamer; Silvère M. van der Maarel; Peter S. Zammit ABSTRACT Skeletal muscle wasting in facioscapulohumeral muscular dystrophy (FSHD) results in substantial morbidity. On a disease-permissive...

... Summary: Collagen VI is a remarkable component of the extracellular matrix, and studies have highlighted a crucial role for this protein in a wide range of tissues under physiological and pathological conditions. Collagen Extracellular matrix Skeletal muscle Collagen VI (ColVI...

... in myofibrillogenesis in chick skeletal muscle: evidence that thin filaments rearrange to form striated myofibrils.   J. Cell Sci.   112 , 1111 – 1123 . Almenar-Queralt   A. , Lee   A. , Conley   C. A. , Ribas de Pouplana   L. , Fowler   V. M. ( 1999b ). Identification of a novel tropomodulin...

... and a decrease in force production in mice with the accumulation of abnormal proteins. To the best of our knowledge, our study is the first to examine the role of the proteasomal system in mammalian skeletal muscle using a loss-of-function strategy. Contrary to our hypothesis and previous studies using...

...Laura Collard; Gaëlle Herledan; Alessandra Pincini; Aline Guerci; Voahangy Randrianarison-Huetz; Athanassia Sotiropoulos ABSTRACT Skeletal muscle atrophy is a debilitating process that is associated with a wide variety of conditions including inactivity, disease and aging. Here, we demonstrate...

...Yu Xin Wang; Nicolas A. Dumont; Michael A. Rudnicki ABSTRACT Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem...

... Skeletal muscle Intermediate filaments (IFs) are filamentous components of the cytoskeleton of 10-nm diameter that mechanically connect various structures of the cytoplasmic space ( Lazarides, 1980 ). The tissue- or cell-type-specific expression of IFs makes most of them useful cell identity...

... to insulin-stimulated glucose transport are unknown. We tested the impact of H 2 O 2 on insulin-dependent glucose transport and GLUT4 translocation in skeletal muscle cells. H 2 O 2 increased the translocation of GLUT4 with an exofacial Myc-epitope tag between the first and second transmembrane domains...

... previous studies have demonstrated that Sharp-1 is a negative regulator of skeletal myogenesis and it blocks differentiation of muscle precursor cells by modulating the activity of MyoD. In order to understand its role in pre- and post-natal myogenesis, we assessed skeletal muscle development and freeze...

...Chibeza C. Agley; Anthea M. Rowlerson; Cristiana P. Velloso; Norman R. Lazarus; Stephen D. R. Harridge Summary We characterised the adherent cell types isolated from human skeletal muscle by enzymatic digestion, and demonstrated that even at 72 hours after isolation these cultures consisted...

... of dysfunctional organelles and protein aggregates, whereas the ubiquitin-proteasome is important for the quality control of proteins. Post-mitotic tissues, such as skeletal muscle, are particularly susceptible to aged or dysfunctional organelles and aggregation-prone proteins. Therefore, these degradation systems...