... . The numerical values of the parameters are provided in Table S1 , unless otherwise stated. The rate of cell volume growth is assumed to be constant (see Fig. 1K in Zatulovskiy et al., 2020 ): and volume is halved at cell division when Cdk1 drops below 0.7. In order to model size-controlled cycling...

... in the cell size control mechanism Fission yeast Mitosis Size control mga2 Steady-state exponentially growing eukaryotic cells tend to divide with a similar size. This is thought to come about by a size control mechanism acting over the progression of the cell cycle, which sets cell size...

... 1999 © 1999 by Company of Biologists 1999 Size control Mitosis Cdc25 Cdc13 Schizosaccharomyces pombe eIF4A Translation initiation Cells double their mass during each division cycle, maintaining a constant size as they proliferate (Mitchinson, 1971). In eukaryotes, cell...

.... However, the size control of this mutant operates in late G 2 , which is different from wild-type (WT) cells. This fact suggests that in WT the rate-limiting molecular process during the G 2 timer is the Tyr15 dephosphorylation of cdc2, for which the cdc25 phosphatase (together with its back-up, pyp3...

...A. Sveiczer; B. Novak; J. M. Mitchison ABSTRACT An analysis was made of cell length and cycle time in time-lapse films of the fission yeast Schizosaccharomyces pombe using wild-type (WT) cells and those of various mutants. The more important conclusions about ‘size controls’ are: (1...

... by a cell cycle block. There is a size control of DNA synthesis which is not cryptic in normal cells but its effect is weaker in large cells than in small cells. We suggest that the entrainment signals from start and from mitosis also operate in the normal cell cycle and that the nature of the signal...

... has lost its mitotic size control, also shows the G 1 block after CO 2 deprivation, but its mitosis is insensitive to CO 2 . Comparing the respiration of wee and wild-type cells we conclude that CO 2 inhibits the citric acid cycle in the wild type. The consequence of these results in the regulation...