..., cohesin was linked to sister chromatid cohesion, the process that ensures the fidelity of chromosome segregation in mitosis. In recent years, a second function in the organization of interphase chromatin into topologically associated domains has been determined, and loop extrusion has emerged...

... and several cohesin auxiliary factors. Sister chromatid cohesion is essential for accurate chromosome segregation during mitosis, yet has also been implicated in other processes, including DNA damage repair, transcription and DNA replication. To assess how cohesin and associated factors functionally...

...-associated CDCA5 , and promote chromosome stability. Cactin Pre-mRNA splicing Sororin Sister chromatid cohesion DHX8 SRRM2 The cactin protein family comprises evolutionarily conserved polypeptides involved in seemingly disparate cellular processes. Isolated at first as an antigen...

...-chromatid cohesion protein ORD and its role in the maintenance of centromeric cohesion . Genetics   146 , 1319 - 1331 . Bickel , S. E. , Orr-Weaver , T. L. and Balicky , E. M. ( 2002 ). The sister-chromatid cohesion protein ORD is required for chiasma maintenance in Drosophila oocytes...

... Ltd 2013 DNA replication Eco1/Ctf7 SMC3 Sister chromatid cohesion Acetylation Condensation One goal of cell division is to ensure that sister chromatids, produced during S phase, become properly segregated into the newly forming daughter cells during mitosis. To accomplish...

.... Here, we describe the roles of Timeless-Tipin in replication fork stabilization and sister chromatid cohesion. We show in human cells that Timeless is recruited to replication origin regions and dissociate from them as replication proceeds. Cdc45, which is known to be required for replication fork...

... maintain sister chromatid cohesion, but the molecular mechanism by which only sisters become paired (termed establishment) is highly controversial. One of the first establishment models posited in the literature suggested that cohesin complexes associated with each sister become tethered together through...

... used hypomorphic small interfering RNAs (siRNAs) to demonstrate that, in addition to playing a role in spindle formation and structure, CDK11 p58 is also required for sister chromatid cohesion and the completion of mitosis. Moderate depletion of CDK11 causes misaligned and lagging chromosomes but does...

...Ana Losada; Tomoki Yokochi; Tatsuya Hirano Sister chromatid cohesion is essential for proper segregation of the genome in mitosis and meiosis. Central to this process is cohesin, a multi-protein complex conserved from yeast to human. Previous genetic studies in fungi have identified Pds5/BimD/Spo76...

... at the second meiotic division, when spindle microtubules from opposite poles attach to sister chromatids. Recent studies have identified novel meiosis-specific kinetochore proteins, such as monopolin and shugoshin, and indicate that specific modifications in sister chromatid cohesion lie at the heart...

... specificity of loss of recombination in the rec8, rec10 and rec11 mutants can be explained by their defects in linear element formation. Investigation of the rec10 mutant showed that linear elements are basically dispensable for sister chromatid cohesion, but contribute to full level pairing of homologous...

...Shao-Win Wang; Rebecca L. Read; Chris J. Norbury Sister chromatid cohesion, which is established during the S phase of the eukaryotic cell cycle and persists until the onset of anaphase, is essential for the maintenance of genomic integrity. Cohesion requires the multi-protein complex cohesin...

... 2001 Meiosis Nondisjunction Sister chromatid cohesion Synaptonemal complex XO mouse Proper chromosome segregation during mitotic cell division requires at least two chromosome-associated protein complexes. At the centromere, functional kinetochores must be formed on individual sister...

... for sister chromatid cohesion at different stages. Just before nuclear envelope breakdown, histone H3 phosphorylation is seen first in the pericentromeric regions and then extends through the arms at metaphase I; at metaphase II only the pericentromeric regions are stained. In afd1 (absence of first division...