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Keywords: Signal transduction
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Journal Articles
J Cell Sci (2021) 134 (3): jcs248393.
Published: 10 February 2021
.... Rho GTPase Signal transduction Trio family Cytoskeleton Neurodevelopmental disorders Cell morphogenesis Trio family proteins are key regulators of cell motility and morphogenesis, tissue development, and protein trafficking and secretion in numerous biological contexts, including their...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs228015.
Published: 11 September 2020
... review of the signaling cascades regulating and regulated by the different isoforms of the p53-related transcription factor p63, as well the role of p63 in disease. Cancer Development Isoforms p63 Stemness Differentiation Signal transduction p63, also known as Trp63 (transformation...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2019) 132 (4): jcs226423.
Published: 11 February 2019
... differentiation 3 (CD3) complex. The spatial organization of the TCR–CD3 complex in the membrane is thought to be a key regulatory element of signal transduction, raising the question of how receptor clustering impacts on TCR triggering. How signal transduction at the TCR–CD3 complex encodes the quality and...
Journal Articles
J Cell Sci (2019) 132 (1): jcs222380.
Published: 02 January 2019
... important tyrosine kinase that regulates various cell functions. We provide the first evidence that Sp1 regulates c-Abl transcription. Conversely, c-Abl modulates Sp1 via ERK1/2. c-Abl Sp1 Smooth muscle Signal transduction Proliferation c-Abl (Abelson tyrosine kinase, Abl) is a non...
Journal Articles
J Cell Sci (2018) 131 (11): jcs212910.
Published: 05 June 2018
..., the photoreceptor melanopsin (Opn4) signals through G proteins βγ and α i and controls several major signaling pathways, which may explain its multi-functionality. Melanopsin Opn4 Retinal GPCR G protein Signal transduction Opsin Non-mammalian vertebrates employ Opn4, a G-protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs209353.
Published: 29 January 2018
... and RLCKs for signal transduction. We further discuss how signaling specificities are maintained through modules at which signals converge, with a focus on SERK-mediated receptor signaling. * Authors for correspondence ( lshan@tamu.edu ; xzmeng@shu.edu.cn ) Competing interests The authors...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2018) 131 (1): jcs211367.
Published: 04 January 2018
... Highlighted Article: The interruption of the intracellular trafficking of Smo before it undergoes lysosome-mediated degradation leads to a high level of Smo accumulation, which is activated independently of ligand stimulation. ESCRT Hh Smo Vps20 Vps32 Signal transduction Hedgehog (Hh...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2808–2820.
Published: 01 September 2017
... altering cellular sensitivity to ligand. Signal transduction RTK endocytosis ShcA ShcD EGFR AP2 Clathrin-mediated endocytosis NES Ubiquitin Cbl Proteins of the Src homology and collagen (Shc) family are best characterised as phosphotyrosine adaptors in signal transduction cascades...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2606–2619.
Published: 01 August 2017
... that CHL1 triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development. * Author for correspondence ( schachner@stu.edu.cn ) Competing interests The authors...
Journal Articles
J Cell Sci (2017) 130 (14): 2292–2305.
Published: 15 July 2017
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 1997–2006.
Published: 15 June 2017
... neurodegenerative, inflammatory and metabolic disorders ( Heideker and Wertz, 2015 ). Deubiquitinase Deubiquitylase Signal transduction Ubiquitylation Summary: This Commentary discusses poorly appreciated paradigms of how DUBs are activated, regulated and targeted to their appropriate substrates...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (11): 1929–1939.
Published: 01 June 2017
... Signal transduction The total pancreatic β-cells mass constitute a small endocrine tissue that is organized, together with other endocrine cells, in islets of Langerhans, which are dispersed throughout the pancreatic exocrine tissue ( Rahier et al., 1983 ). β-cells sense glucose and other...
Journal Articles
J Cell Sci (2017) 130 (3): 531–540.
Published: 01 February 2017
... Stains , J. P. ( 2014 ). Gap junctional regulation of signal transduction in bone cells . FEBS Lett.   588 , 1315 - 1321 . 10.1016/j.febslet.2014.01.025 Buo , A. M. , Williams , M. S. , Kerr , J. P. and Stains , J. P. ( 2016 ). A cost-effective method to enhance...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (22): 4175–4189.
Published: 15 November 2016
.../ Highlighted Article: The receptor CD36 exists in nanoclusters enriched with the downstream effector Fyn when unligated; multivalent ligands enhance the clusters and activate Fyn, bypassing de novo recruitment of Fyn to the clusters. CD36 Receptor and membrane biology Signal transduction Src-family...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4642–4652.
Published: 15 December 2015
... hippocampal GABAergic neurons, and that 5-HT2c receptor phosphorylation and its association with phosphatase and tensin homolog (PTEN) and β-arrestin 2 is regulated by CHL1. Our results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby...
Journal Articles
J Cell Sci (2015) 128 (22): 4074–4082.
Published: 15 November 2015
... of STIM1 through its luminal domain to junctate ( Srikanth et al., 2012 )]. Ca 2+ Capacitive calcium entry Ion channel Junctate Signal transduction Membrane contact site Phagocytosis Highlighted Article: The STIM1-interacting protein junctate generates Ca 2+ hotspots that...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3155–3163.
Published: 15 August 2015
... CaM-interaction sites is impaired. Calmodulin PIP 2 KCNQ M-current Signal transduction Kv7.2 (also known as KCNQ2) is the main channel mediating the non-inactivating K + M-current, which opens at subthreshold membrane potentials, providing a brake for membrane excitation...
Journal Articles
J Cell Sci (2015) 128 (12): 2236–2248.
Published: 15 June 2015
... receptor signal transduction . Sci. STKE   2001 , re21 . 10.1126/stke.2001.112.re21 Mizushima , N. , Yoshimori , T. and Levine , B. ( 2010 ). Methods in mammalian autophagy research . Cell   140 , 313 - 326 . 10.1016/j.cell.2010.01.028 Monvoisin , A. , Alva , J. A...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (23): 5115–5125.
Published: 01 December 2014
... differentiated Dictyostelium discoideum cells to investigate whether localized receptor stimuli can induce the spreading of excitable waves in the G-protein-dependent signal transduction system. By imaging the spatiotemporal dynamics of fluorescent markers for phosphatidylinositol (3,4,5)-trisphosphate (PIP 3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4518–4530.
Published: 15 October 2014
... microtubule dynamic instability using a plus-end growth marker.   Nat. Methods   7 , 761 – 768 . 10.1038/nmeth.1493 Matsumoto   T. , Claesson-Welsh   L. ( 2001 ). VEGF receptor signal transduction.   Sci. STKE   2001 , re21 . Morfini   G. A. , Burns   M. , Binder   L. I...
Includes: Supplementary data