...Shaka X; Claire Aitken; Vedanta Mehta; Blanca Tardajos-Ayllon; Jovana Serbanovic-Canic; Jiayu Zhu; Bernadette Miao; Ellie Tzima; Paul Evans; Yun Fang; Martin A. Schwartz ABSTRACT Fluid shear stress (FSS) from blood flow, sensed by the vascular endothelial cells (ECs) that line all blood vessels...

... on 2 kPa gels maximally boost local invasion and confer resistance to flow-induced shear stresses. Collectively, our results suggest that homing of MSCs at the pre-metastatic stage and their differentiation into CAFs actively drives breast cancer invasion and metastasis in TNBC. * Author...

...Jaime A. Espina; Marilia H. Cordeiro; Milan Milivojevic; Ivana Pajić-Lijaković; Elias H. Barriga ABSTRACT Shear stress is essential for normal physiology and malignancy. Common physiological processes – such as blood flow, particle flow in the gut, or contact between migratory cell clusters...

... interests. 16 8 2021 25 3 2022 © 2022. Published by The Company of Biologists Ltd 2022 Highlighted Article: Dictyostelium PkcA controls stationary phase entry by negatively regulating polyphosphate concentration and F-actin polymerization under high shear stress, in turn...

.... Evans ABSTRACT Endothelial cell (EC) sensing of fluid shear stress direction is a critical determinant of vascular health and disease. Unidirectional flow induces EC alignment and vascular homeostasis, whereas bidirectional flow has pathophysiological effects. ECs express several mechanoreceptors...

... leads to severe distortions of adherens junctions (AJs), as well as tight junctions, accompanied by an upregulation of actin stress fibres and increased cellular contractility. Plectin-deficient endothelial cell layers were more leaky and showed reduced mechanical resilience in fluid-shear stress...

... and smooth muscle cells (SMCs). The microenvironment of vascular cells not only contains biochemical factors that influence differentiation, but also exerts hemodynamic forces, such as shear stress and cyclic strain. Recent evidence has shown that these forces can influence the differentiation of MSCs...

...Wendong Fan; Rong Fang; Xiaoyuan Wu; Jia Liu; Mingzhe Feng; Gang Dai; Guojun Chen; Guifu Wu ABSTRACT Although many studies have described the roles of microRNAs (miRNAs) in the modulation of the endothelial response to shear stress, the mechanisms remain incompletely understood. Here, we...

...Kimiko Yamamoto; Joji Ando Summary Endothelial cells (ECs) sense shear stress and transduce blood flow information into functional responses that play important roles in vascular homeostasis and pathophysiology. A unique feature of shear-stress-sensing is the involvement of many different types...

... of mature blood vessels. We demonstrate, using a Vegf–lacZ reporter mouse model, that VEGF is expressed by arterial but not by venous or capillary endothelial cells (ECs) in vivo. Using an in vitro model, we show that arterial shear stress of human umbilical vein ECs (HUVECs) decreases apoptosis...

...Kimiko Yamamoto; Kishio Furuya; Makiko Nakamura; Eiry Kobatake; Masahiro Sokabe; Joji Ando Endothelial cells (ECs) release ATP in response to shear stress, a fluid mechanical force generated by flowing blood but, although its release has a crucial role in controlling a variety of vascular functions...

...Christopher L. Avvisato; Xiang Yang; Salim Shah; Becky Hoxter; Weiqun Li; Richard Gaynor; Richard Pestell; Aydin Tozeren; Stephen W. Byers At various stages during embryogenesis and cancer cells are exposed to tension, compression and shear stress; forces that can regulate cell proliferation...

... interstitial fluid flow – may itself play an important role in fibrogenesis. * Author for correspondence (e-mail: [email protected] ) 1 8 2005 © The Company of Biologists Limited 2005 2005 Fibrosis α-Smooth muscle actin Transforming growth factor β β 1 Integrin Shear stress...

... such a relationship is relevant to endothelial cells under flow. The present study was undertaken to provide an indepth investigation of the relationship between shear stress, GA/MTOC localization, cell migration and nuclear position. Bovine carotid endothelial cells were exposed to 22 or 88 dynes/cm 2 for 0.5, 2, 8...