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Keywords: Sex determination
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Journal Articles
J Cell Sci (2019) 132 (8): jcs223768.
Published: 15 April 2019
... of the gonadal primordia of both sexes, but, after sex determination, it is upregulated in XY testes and downregulated in XX ovaries. We have recently demonstrated, in mice, that this downregulation is mediated by forkhead box L2 (FOXL2) and hypothesized that adequate suppression of Nr5a1 is essential for normal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2717–2724.
Published: 15 August 2010
...Esther Zanin; Anne Pacquelet; Claudia Scheckel; Rafal Ciosk; Monica Gotta LA-related protein 1 (LARP-1) belongs to an RNA-binding protein family containing a LA motif. Here, we identify LARP-1 as a regulator of sex determination. In C. elegans hermaphrodites, a complex regulatory network regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3663–3672.
Published: 15 October 2009
..., the p97/CDC-48–UFD-1–NPL-4 complex interacted with the E3 ubiquitin ligase CUL-2 complex via NPL-4 binding to Elongin C. Furthermore, TRA-1A, which is the terminal effector of the sex determination pathway and is regulated by CUL-2-mediated proteolysis, accumulated in the cdc-48.1 mutant. Proteasome...
Journal Articles
J Cell Sci (2003) 116 (9): 1653–1658.
Published: 01 May 2003
..., A., Guo, J. K., Lutsch, G., Leheste, J. R., Landrock,D., Ziegler, U., Gubler, M. C. and Schedl, A. ( 2001 ). Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106 , 319 -329. Hastie, N. D. ( 1994 ). The genetics...
Journal Articles
J Cell Sci (2003) 116 (3): 441–445.
Published: 01 February 2003
...Enzo Lalli; Kenji Ohe; Elisa Latorre; Marco E. Bianchi; Paolo Sassone-Corsi A remarkable array of strategies is used to produce sexual differentiation in different species. Complex gene hierarchies govern sex determination pathways, as exemplified by the classic D. melanogaster paradigm,where...