...Håkan C. Steen; Kevin P. Kotredes; Shoko Nogusa; Michele Y. Harris; Siddharth Balachandran; Ana M. Gamero ABSTRACT Serine phosphorylation of STAT proteins is an important post-translational modification event that, in addition to tyrosine phosphorylation, is required for strong transcriptional...

...) confirming Src family kinases regulated receptor phosphorylation. However, cells expressing phospho-defective Y143F-S1PR1 mutant showed, as expected, no phosphorylation in response to S1P (Fig. 3C). We next examined the role of serine phosphorylation of S1PR1 at the five serine residues located at C...

...) 17 9 2009 © The Company of Biologists Limited 2009 2009 Protein kinase C NQO1 ARE Nrf2 INrf2 (Keap1) Serine phosphorylation Detoxifying enzyme Nuclear factor erythroid 2-related factor 2 (Nrf2) binds to antioxidant response element (ARE) and regulates expression...

... of Biologists Limited 2009 2009 Rho GTPases Actin cytoskeleton Protein kinases C and D Serine phosphorylation Tumor suppressor The DLC1 gene was first isolated as a candidate tumor suppressor gene in primary human hepatocellular carcinoma and loss of expression has subsequently been shown...

...Marina Gartsbein; Addy Alt; Koji Hashimoto; Koichi Nakajima; Toshio Kuroki; Tamar Tennenbaum Activation of the STAT family of transcription factors is regulated by cytokines and growth factors. STAT tyrosine and serine phosphorylation are linked to the transcriptional activation and function...