...Koyomi Nakazawa; Gaurav Kumar; Brieuc Chauvin; Aurélie Di Cicco; Luca Pellegrino; Michael Trichet; Bassam Hajj; João Cabral; Anirban Sain; Stéphanie Mangenot; Aurélie Bertin ABSTRACT Septins are cytoskeletal proteins interacting with the inner plasma membrane and other cytoskeletal partners. Being...

...-autonomous immune responses including antibacterial autophagy and septin cage entrapment. How septins interact with the autophagy process to target Shigella for destruction is poorly understood. Here, we employed a correlative light and cryo-soft X-ray tomography (cryo-SXT) pipeline to study Shigella septin...

... identified 922 proteins consistently represented in both interphase and mitotic cortices. Focusing on actin-related proteins narrowed down the list to 238 candidate regulators of the mitotic cortical tension increase. Among these candidates, we found that there is a role for septins in mitotic cell rounding...

.... These infection cells develop in response to the physical characteristics of the leaf surface, starvation stress and signals from the plant. Appressorium morphogenesis has been linked to septin-mediated reorganisation of F-actin and microtubule networks of the cytoskeleton, and remodelling of the fungal cell wall...

...Shengnan Zheng; Biyu Zheng; Zhenbang Liu; Xiaopeng Ma; Xing Liu; Xuebiao Yao; Wenfan Wei; Chuanhai Fu ABSTRACT Septins are a family of filament-forming GTP-binding proteins that regulate fundamental cellular activities, such as cytokinesis and cell polarity. In general, septin filaments function...

... ABSTRACT Septins, a family of GTP-binding proteins that assemble into higher order structures, interface with the membrane, actin filaments and microtubules, and are thus important regulators of cytoarchitecture. Septin 9 (SEPT9), which is frequently overexpressed in tumors and mutated in hereditary...

... disease. Appressorium functionality is dependent on the formation of a cortical septin ring during its morphogenesis, but precisely how this structure assembles is unclear. Here, we show that F-actin rings are recruited to the circumference of incipient septin disc-like structures in a pressure-dependent...

... opportunities for the treatments against osteoporosis, as reviewed here. Intermediate filament Microtubule Osteoclast Osteoporosis Rho GTPase Septin Centre National de la Recherche Scientifique 10.13039/501100004794 Montpellier University Fondation pour la Recherche...

... work is properly attributed. Summary: The pathogen Shigella forms actin tails to move through the cytosol of infected cells. We show that the bacterial actin homologue MreB can help to position the autotransporter protein IcsA for such actin tail formation. Actin IcsA MreB Septin...

...Hoan Van Ngo; Serge Mostowy ABSTRACT Septins are widely recognized as a component of the cytoskeleton that is essential for cell division, and new work has shown that septins can recognise cell shape by assembling into filaments on membrane regions that display micrometer-scale curvature (e.g...

... importance to eukaryotic cell function. While plasma membrane compartmentalization and dynamics are well known to depend on the scaffolding function of septin GTPases, the roles of septins at intracellular membranes have remained largely elusive. Here, we show that the structural and functional integrity...

... appears to associate with septins, a family of cytoskeletal- and membrane-associated proteins. In establishing that these interactions are sufficient for SNX21 to recruit Htt and septins on to an endosomal population, we reveal a scaffolding function for this sorting nexin. Our work paves the way...

... ethanol concentration [10% (v/v)] on yeast morphology. We found that long-term severe ethanol stress induced the continuous depolarization of the actin cytoskeleton and hypertrophy in yeast cells, accompanied by the aberrant localization of septins, which formed multiple small cortical rings (MSCRs...

... proteins, and damaged or superfluous organelles, and deliver them to the lysosome for degradation. Septins are conserved GTP-binding proteins involved in many cellular processes, including phagocytosis and the autophagy of intracellular bacteria, but no role in general autophagy was known. In budding yeast...

...Sabrina Zander; Sebastian Baumann; Stefanie Weidtkamp-Peters; Michael Feldbrügge ABSTRACT Septins are conserved cytoskeletal structures functioning in a variety of biological processes including cytokinesis and cell polarity. A wealth of information exists on the heterooligomeric architecture...

... cytoskeletal proteins involved, septins are known to be essential mediators of cytokinesis. In this Commentary, we present recent observations that specific cell divisions can proceed in the absence of the core mammalian septin SEPT7 and its Drosophila homolog Peanut (Pnut) and that thus challenge the view...

...Bingkun Lei; Nan Zhou; Yuchen Guo; Wenqi Zhao; Yan-Wen Tan; Yao Yu; Hong Lu ABSTRACT Accurate cell division requires the proper assembly of high-order septin structures. In fission yeast ( Schizosaccharomyces pombe ), Spn1–Spn4 are assembled into a primary septin ring at the division site...

... studied the effects of L428A/L429A mutation on the interactome, localization and stability of LCA expressed in cultured neuronal cells. Mass spectrometry analysis of the LCA interactome showed that the mutation prevented the interaction of LCA with septins. The wild-type LCA was concentrated in plasma...

... evidence that yeast epsin 2 (Ent2) plays a signaling role during cell division. We observed that overexpression of the ENTH domain of Ent2 (ENTH2), but not Ent1, promoted the formation of chains of cells and aberrant septa. This dominant-negative effect resulted from ENTH2-mediated interference with septin...

...Chang-Run Li; Raymond Teck-Ho Lee; Yan-Ming Wang; Xin-De Zheng; Yue Wang The growing tips of Candida albicans hyphae are sites of polarized exocytosis. Mammalian septins have been implicated in regulating exocytosis and C. albicans septins are known to localize at hyphal tips, although...