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Keywords: Senescence
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Journal Articles
Journal Articles
J Cell Sci (2022) 135 (10): jcs259513.
Published: 25 May 2022
... humans and mice have shown that TPPII deficiency is linked to cellular immune-senescence, lifespan regulation and the aging process. However, the mechanism of how TPPII participates in these processes is less clear. In this study, we established a chemical probe-based assay and found that although...
Includes: Supplementary data
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J Cell Sci (2019) 132 (13): jcs229385.
Published: 1 July 2019
.... Following this mitotic slippage, cells with decreased DNA-PKcs underwent accelerated cellular senescence. We identified downregulation of ataxia-telangiectasia mutated kinase (ATM) as the critical role of DNA-PKcs in recovery from DNA damage, insofar as targeting ATM restored γH2AX foci resolution...
Includes: Supplementary data
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J Cell Sci (2018) 131 (23): jcs216804.
Published: 30 November 2018
..., but also in quiescent, senescent and terminally differentiated cells. During mitosis, residual endocytosis is dedicated to the internalization of caveolae and specific receptors. In non-dividing cells, clathrin-mediated endocytosis (CME) functions, but the activity of alternative processes...
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J Cell Sci (2017) 130 (19): 3272–3281.
Published: 1 October 2017
... activator (tPA). Interestingly, serpinB2 levels are increased in senescent cells and serpinB2 is thus considered a senescence biomarker. In this study, by mimicking the elevated levels of serpinB2 in senescent cells, proliferating human fibroblasts were induced into senescence. Senescence induced...
Includes: Supplementary data
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Metabolism
J Cell Sci (2017) 130 (8): 1413–1420.
Published: 15 April 2017
...Taiki Nagano; Akio Nakashima; Kengo Onishi; Kosuke Kawai; Yuto Awai; Mizuki Kinugasa; Tetsushi Iwasaki; Ushio Kikkawa; Shinji Kamada ABSTRACT Cellular senescence is a complex stress response characterized by permanent loss of proliferative capacity and is implicated in age-related disorders...
Journal Articles
J Cell Sci (2016) 129 (5): 912–920.
Published: 1 March 2016
... of senescence-associated β-galactosidase activity. Investigation of cell cycle factors revealed that transient activation of Nanog correlates with consistent downregulation of the cell cycle inhibitor p27 KIP1 (also known as CDKN1B). By performing chromatin immunoprecipitation analysis, we confirmed bona fide...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 293–304.
Published: 15 January 2015
...William W. Du; Xianmin Li; Tianbi Li; Haoran Li; Azam Khorshidi; Fengqiong Liu; Burton B. Yang ABSTRACT The microRNA miR - 17-92 cluster plays a fundamental role in heart development. The aim of this study was to investigate the effect of a member of this cluster, miR-17, on cardiac senescence. We...
Includes: Supplementary data
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J Cell Sci (2012) 125 (1): 7–17.
Published: 1 January 2012
... functions of many of these miRNAs are still unknown. Recently, various miRNAs have been identified that are up- or down-regulated during mammalian aging by comparing their tissue-specific expression in younger and older mice. In addition, many miRNAs have been implicated in governing senescence in a variety...
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In collection:
Proteostasis
J Cell Sci (2007) 120 (18): 3219–3227.
Published: 15 September 2007
... within the evolutionarily conserved C-terminus of PML-I. This domain contains a predicted exonuclease III fold essential for the targeting of the PML-I C-terminus to nucleolar fibrillar centres. Furthermore, spontaneous or oncogene retrieval-induced senescence is associated with the formation of very...
Includes: Multimedia, Supplementary data
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Journal Articles
J Cell Sci (2007) 120 (5): 737–747.
Published: 1 March 2007
... phase in proliferating cells and upon cell cycle exit in quiescence, senescence and differentiation. Upon cell cycle exit LINT-25 accumulated in heterochromatin foci, and LAP2α protein levels were downregulated by proteasomal degradation. Although LAP2α was not required for the upregulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (12): 2435–2443.
Published: 15 June 2006
...S.-H. Kim; J. Rowe; H. Fujii; R. Jones; B. Schmierer; B.-W. Kong; K. Kuchler; D. Foster; D. Ish-Horowicz; G. Peters In mammalian cells, products of the INK4a-ARF locus play major roles in senescence and tumour suppression in different contexts, whereas the adjacent INK4b gene is more generally...
Journal Articles