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Keywords: Self-renewal
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Journal Articles
In collection:
Stem Cells
J Cell Sci (2017) 130 (22): 3809–3817.
Published: 15 November 2017
...Kuisheng Liu; Yan Zhang; Dahai Liu; Qi-Long Ying; Shoudong Ye ABSTRACT TFCP2L1 is a transcription factor that is crucial for self-renewal of mouse embryonic stem cells (mESCs). How TFCP2L1 maintains the pluripotent state of mESCs, however, remains unknown. Here, we show that knockdown of Tfcp2l1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (2): 269–276.
Published: 15 January 2016
...Shoudong Ye; Dongming Zhang; Fei Cheng; Daniel Wilson; Jeffrey Mackay; Kan He; Qian Ban; Feng Lv; Saifei Huang; Dahai Liu; Qi-Long Ying ABSTRACT Activation of leukemia inhibitor factor (LIF)–Stat3 or Wnt/β-catenin signaling promotes mouse embryonic stem cell (mESC) self-renewal. A myriad...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2015) 128 (21): 3849–3860.
Published: 01 November 2015
...Marija Vlaski-Lafarge; Zoran Ivanovic ABSTRACT Many studies have provided evidence for the crucial role of the reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the regulation of differentiation and/or self-renewal, and the balance between quiescence and proliferation...
Journal Articles
J Cell Sci (2014) 127 (18): 3885–3891.
Published: 15 September 2014
...Robert Y. L. Tsai ABSTRACT A quintessential trait of stem cells is embedded in their ability to self-renew without incurring DNA damage as a result of genome replication. One key self-renewal factor is the nucleolar GTP-binding protein nucleostemin (also known as guanine-nucleotide-binding protein...
Journal Articles
J Cell Sci (2014) 127 (12): 2603–2613.
Published: 15 June 2014
...Tim Pieters; Frans van Roy ABSTRACT Pluripotent embryonic stem cells (ESCs) can self-renew or differentiate into any cell type within an organism. Here, we focus on the roles of cadherins and catenins – their cytoplasmic scaffold proteins – in the fate, maintenance and differentiation of mammalian...
Journal Articles
J Cell Sci (2013) 126 (18): 4220–4229.
Published: 15 September 2013
...Qiong Wu; Zhiping Yang; Fang Wang; Sijun Hu; Li Yang; Yongquan Shi; Daiming Fan Summary Human gastric cancers contain a population of gastric cancer stem cells (GCSCs) that can undergo self-renewal and multipotent differentiation. GCSCs can be enriched with EpCAM+/CD44+ gastric cancer cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1093–1098.
Published: 01 March 2013
...Chih-I Tai; Qi-Long Ying Summary Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal and also facilitates reprogramming to ground state pluripotency. Exactly how LIF/Stat3 signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (4): 1009–1020.
Published: 15 February 2013
... camera and CellSens acquisition software (Olympus, USA). * Author for correspondence ( joatley@vetmed.wsu.edu ) 23 11 2012 © 2013. Published by The Company of Biologists Ltd 2013 Spermatogonial stem cell CXCL12–CXCR4 Self-renewal Migration Niche The homeostasis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5609–5620.
Published: 01 December 2012
... outcome. A growing number of small molecules have been identified to maintain the self-renewal potential of stem cells, to induce lineage differentiation and to facilitate reprogramming by increasing the efficiency of reprogramming or by replacing genetic reprogramming factors. Furthermore, mechanistic...
Journal Articles
J Cell Sci (2012) 125 (5): 1309–1317.
Published: 01 March 2012
..., stimulated to proliferate and then sorted by FACS. The vast majority of activated satellite cells were PKH26 low fast-dividing cells, whereas PKH26 high slow-dividing cells were observed as a minority population. The fast-dividing cells generated a higher number of differentiated and self-renewed cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2654–2665.
Published: 01 August 2011
...Jesse L. Cox; Sunil K. Mallanna; Briana D. Ormsbee; Michelle Desler; Matthew S. Wiebe; Angie Rizzino Self-renewal is a complex biological process necessary for maintaining the pluripotency of embryonic stem cells (ESCs). Recent studies have used global proteomic techniques to identify proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1775–1783.
Published: 01 June 2011
... in the maintenance of stem cells are less well understood. However, with recent advances, their role as a rheostat that fine-tunes stem cell self-renewal has begun to emerge. Finally, we discuss future studies that will hopefully lead to a comprehensive understanding of the miRNA pathway in stem cells. References...
Journal Articles
J Cell Sci (2011) 124 (7): 1136–1144.
Published: 01 April 2011
...Christoffer Tamm; Nathalie Böwer; Cecilia Annerén The cytoplasmic tyrosine kinase Yes has previously been shown to have an important role in maintaining mouse and human embryonic stem (ES) self-renewal through an unknown pathway downstream of leukemia inhibitory factor (LIF) and one or more factors...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (14): 2357–2368.
Published: 15 July 2010
...Malcolm R. Alison; Shahriar Islam; Nicholas A. Wright There is growing realization that many – if not all – cancer-cell populations contain a subpopulation of self-renewing stem cells known as cancer stem cells (CSCs). Unlike normal adult stem cells that remain constant in number, CSCs can increase...
Journal Articles
J Cell Sci (2009) 122 (24): 4427–4438.
Published: 15 December 2009
... their myogenic differentiation, but reducing their self-renewal. Transfection with siRNA against PS1 led to accelerated myogenic differentiation during muscle regeneration in vivo. Conversely, constitutive expression of PS1 resulted in the suppression of myogenic differentiation and promotion of the self-renewal...
Journal Articles
J Cell Sci (2008) 121 (23): 3941–3950.
Published: 01 December 2008
...Laura Kerosuo; Katja Piltti; Heli Fox; Alexandre Angers-Loustau; Valtteri Häyry; Martin Eilers; Hannu Sariola; Kirmo Wartiovaara The mechanisms underlying the decision of a stem or progenitor cell to either self-renew or differentiate are incompletely understood. To address the role of Myc...
Journal Articles
J Cell Sci (2008) 121 (16): 2629–2634.
Published: 15 August 2008
...Silvia Parisi; Fabiana Passaro; Luigi Aloia; Ichiro Manabe; Ryozo Nagai; Lucio Pastore; Tommaso Russo Self-renewal of embryonic stem cells (ESCs) is maintained by a complex regulatory mechanism involving transcription factors Oct3/4 (Pou5f1), Nanog and Sox2. Here, we report that Klf5, a Zn-finger...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (9): 1373–1382.
Published: 01 May 2008
...Ana Perez-Ruiz; Yusuke Ono; Viola F. Gnocchi; Peter S. Zammit Satellite cells are the resident stem cells of adult skeletal muscle. As with all stem cells, how the choice between self-renewal or differentiation is controlled is central to understanding their function. Here, we have explored...
Journal Articles
J Cell Sci (2007) 120 (1): 55–65.
Published: 01 January 2007
...Kazuya Ogawa; Akira Saito; Hisanori Matsui; Hiroshi Suzuki; Satoshi Ohtsuka; Daisuke Shimosato; Yasuyuki Morishita; Tetsuro Watabe; Hitoshi Niwa; Kohei Miyazono Embryonic stem (ES) cells are self-renewing cells that maintain pluripotency to differentiate into all types of cells. Because...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (9): 1824–1832.
Published: 01 May 2006
.... Development 120 , 603 -612. Collins, C. A., Olsen, I., Zammit, P. S., Heslop, L., Petrie, A., Partridge, T. A. and Morgan, J. E. ( 2005 ). Stem cell function, self-renewal and behavioural heterogeneity of cells from the adult muscle satellite cell niche. Cell 122 , 289 -301. Conboy, I. M...