... availability and cellular stress. Damaged or superfluous peroxisomes are removed mainly by pexophagy, the selective autophagy of peroxisomes induced by ubiquitylation of peroxisomal membrane proteins or ubiquitin-independent processes. Dysregulated pexophagy impairs peroxisome homeostasis and has been linked...

... mitochondria are recognized and targeted to lysosomes for degradation under different physiological conditions to maintain cellular homeostasis. Mitochondria Mitophagy SLR PINK1 Parkin HIF1 BNIP3 NIX Selective autophagy Medical Research Council http://dx.doi.org/10.13039/501100000265...

... for tumor immunotherapy . Mol. Cancer 18 , 17 . 10.1186/s12943-019-0944-z Johansen , T. and Lamark , T . ( 2020 ). Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors . J. Mol. Biol. 432 , 80 - 103 . 10.1016/j.jmb.2019.07.016 Kaur , J...

... as how its deregulation is involved in multiple human diseases. p62 Sqstm1 Selective autophagy Phase separation Keap1–Nrf2 system Proteinopathies Japan Society for the Promotion of Science 10.13039/501100001691 18H02611 Takeda Science Foundation 10.13039/100007449...

...Alberto Danieli; Sascha Martens ABSTRACT The degradation of misfolded proteins is essential for cellular homeostasis. Misfolded proteins are normally degraded by the ubiquitin-proteasome system (UPS), and selective autophagy serves as a backup mechanism when the UPS is overloaded. Selective...

... response (DDR) to DNA interstrand crosslinks. However, proteins of the FA pathway have additional cytoprotective functions that may be independent of DDR. We have shown that many FA proteins participate in the selective autophagy pathway that is required for the destruction of unwanted intracellular...

...Michael A. Mandell; Ashish Jain; Suresh Kumar; Moriah J. Castleman; Tahira Anwar; Eeva-Liisa Eskelinen; Terje Johansen; Rytis Prekeris; Vojo Deretic ABSTRACT TRIM proteins contribute to selective autophagy, a process whereby cells target specific cargo for autophagic degradation. In a previously...

...Atsushi Eino; Shun Kageyama; Takefumi Uemura; Hiromichi Annoh; Tetsuya Saito; Ichiei Narita; Satoshi Waguri; Masaaki Komatsu ABSTRACT Sqstm1 serves as a signaling hub and receptor for selective autophagy. Consequently, dysregulation of Sqstm1 causes imbalances in signaling pathways and disrupts...

... with the energy demand. This view has recently changed dramatically following an array of papers describing various forms of selective autophagy. A main driving force has been the discovery of specific autophagy receptors that sequester cargo into forming autophagosomes (phagophores). At the heart...

... of organelles to autophagosomes for degradation. Here we demonstrate that substrate selectivity may be partly conferred by the autophagy receptors themselves. Using peroxisomes as substrates for selective autophagy we showed that NBR1, and not p62, is necessary and sufficient for the turnover of endogenous...