...Fangyuan Zhou; Fang Zhang; Veronika I. Zarnitsyna; Larissa Doudy; Zhou Yuan; Kaitao Li; Rodger P. McEver; Hang Lu; Cheng Zhu ABSTRACT Selectins and integrins are key players in the adhesion and signaling cascade that recruits leukocytes to inflamed tissues. Selectin binding induces β 2 integrin...

...Peng-Sheng Zheng; Dana Vais; David LaPierre; Yao-Yun Liang; Vivian Lee; Bing L. Yang; Burton B. Yang P-selectin glycoprotein ligand-1 (PSGL-1), a glycoprotein expressed on the cell surface of leukocytes, binds to selectins and mediates leukocyte rolling on the vascular endothelium. Here we report...

...William D. Hanley; Denis Wirtz; Konstantinos Konstantopoulos Leukocytes are recruited from the bloodstream to sites of inflammation by the selectin family of adhesion receptors. In vivo and in vitro studies reveal distinctive rolling velocities of polymorphonuclear leukocytes over E-, P- and L...

...Martin Steegmaier; Eric Borges; Jürgen Berger; Heinz Schwarz; Dietmar Vestweber ABSTRACT Neutrophils and subsets of lymphocytes bind to E-selectin, a cytokine inducible adhesion molecule on endothelial cells. The E-selectin-ligand-1 (ESL-1) is a high affinity glycoprotein ligand which participates...