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Keywords: Securin
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Journal Articles
In collection:
Cell cycle
J Cell Sci (2024) 137 (6): jcs257675.
Published: 27 March 2024
... investigated the role of the canonical spindle assembly (SAC) pathway in Caenorhabditis elegans spermatogenesis. We found the intensity of chromosome-associated outer kinetochore protein BUB-1 and SAC effector MDF-1 oscillates between the two divisions. However, the SAC target securin is degraded during...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (11): 1825–1831.
Published: 1 June 2008
...M. Cristina Limón-Mortés; Mar Mora-Santos; Águeda Espina; José A. Pintor-Toro; Antonio López-Román; María Tortolero; Francisco Romero Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid separation until the onset of anaphase...
Journal Articles
J Cell Sci (2006) 119 (16): 3325–3336.
Published: 15 August 2006
...Andrew J. Holland; Stephen S. Taylor Separase, the cysteine protease that cleaves cohesin and thereby triggers chromosome disjunction, is inhibited by both securin- and phosphorylation-dependent cyclin B1 binding. Using a novel phosphorylation-specific antibody, we show that mitotic-specific...
Includes: Multimedia, Supplementary data