... in several cell compartments. In mammals, acetyl-CoA transporter 1 (AT1, also known as SLC33A1) facilitates the flux of cytosolic acetyl-CoA into the endoplasmic reticulum (ER), enabling the acetylation of proteins of the secretory pathway, in concert with the activity of dedicated acetyltransferases...

... of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix...

... that disruption of the longer form, TANGO1L, results in relatively minor defects in secretory pathway organization and function, including having limited impacts on procollagen secretion. In contrast, loss of both long and short forms results in major defects in cell organization and secretion. These include...

... activation. One of the MCMV immunoevasins, gp40 ( m152 ), downregulates the cell surface NKG2D ligand RAE-1γ (also known as Raet1c) thus limiting NK cell activation. This study establishes the molecular mechanism by which gp40 retains RAE-1γ in the secretory pathway. Using flow cytometry and pulse-chase...

... are located along the secretory pathway, which ensure the fidelity of such protein signals (quality control). Proteins that pass the checkpoints operated in the endoplasmic reticulum (ER) by the binding immunoglobulin protein (BiP; also known as HSPA5 and GRP78) and the calnexin–calreticulin systems, must...

... regarding various steps of protein transport. Regulation of their functions is achieved by protein interactions but also by post-translational modifications of tubulin. Golgi complex Membrane trafficking Microtubules Secretory pathway Centre National de la Recherche Scientifique 10.13039...

... in a tissue-specific and differentiation-dependent manner. While previous work has focussed on transcriptional and post-translational regulatory mechanisms, the impact of AS on the secretory pathway remains largely unexplored. Here, we integrate results from a published screen for modulators of protein...

... and ATase2 (also known as NAT8B and NAT8, respectively). This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact...

...Alexandre Vernay; Otmane Lamrabet; Jackie Perrin; Pierre Cosson ABSTRACT Previous studies have shown that TM9SF4 interacts with glycine-rich transmembrane domains (TMDs) and promotes their surface localization, presumably by escorting them along the secretory pathway. Here, we delineated the role...

... of transport factors and the expansion of the Golgi to synchronize the rise in cargo load with the amplified capacity of the secretory pathway. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 15 9 2017...

... by a mechanism upstream of Sar1 and COPII, and also blocks exit from the trans-Golgi network. VSVG ER exit sites ER export COP II Secretory pathway Secretion Trans-Golgi network Deutsche Forschungsgemeinschaft 10.13039/501100001659 KA1751/4-1 Japan Society for the Promotion...

..., carrier formation and long-range transport events. Endoplasmic reticulum ER exit sites Protein sorting Microtubules Secretory pathway FRAP Modeling Biosynthetic cargo is sorted at the endoplasmic reticulum (ER) into COPII-coated transport carriers that mediate transport from the ER...

... in any medium provided that the original work is properly attributed. Summary: TM9 proteins facilitate transport to the cell surface of proteins with gylcine-rich transmembrane domains. They might represent a new class of cargo receptors controlling transport in the secretory pathway. Phg1...

... or financial interests. 3 04 2014 28 01 2015 © 2015. Published by The Company of Biologists Ltd 2015 Sar1 Golgi dynamics Live-cell imaging Secretory pathway The Golgi in mammalian cells is a highly organized organelle that consists of several stacks of flattened, membrane...

.... These Bem3-positive structures were polarized towards sites of bud emergence and were mostly observed during the pre-mitotic phase of apical growth. Cell biological and biochemical approaches demonstrated that this intracellular Bem3 compartment contained markers for both the endocytic and secretory pathways...

... of Biologists Ltd 2013 COPII Secretory pathway ER Protein phosphorylation Cell cycle Chs2p One of the yeast chitin synthases, Chs2p, synthesizes the primary septum which separates mother and daughter cells at the bud-neck late in mitosis. Chs2p is transported to the bud-neck via the secretory...

... ( [email protected] ) 16 8 2011 © 2012. 2012 ADP-ribosylation factor (Arf) COPI Extracellular matrix (ECM) Guanine nucleotide exchange factor (GEF) Intracellular trafficking Lipid homeostasis Secretory pathway Tubulogenesis Tube formation in multicellular...

... in secretory pathway-associated functions. Using this approach with dog pancreatic rough microsomes, we found that mitochondrial Bcl-2 inhibitor of transcription (BIT1) localized in the early secretory pathway and accumulated in the Golgi complex. Using both a chimeric protein of the luminal and transmembrane...

...Catherine L. Jackson The Golgi complex is the central sorting and processing station of the secretory pathway, ensuring that cargo proteins, which are synthesized in the endoplasmic reticulum, are properly glycosylated and packaged into carriers for transport to their final destinations. Two recent...

.... * Author for correspondence (e-mail: [email protected] ) 17 4 2008 © The Company of Biologists Limited 2008 2008 Secretory pathway Golgi GRASP Splice variant Plasmodium Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium. Up to 500...