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Keywords: Secretion
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Journal Articles
J Cell Sci (2019) 132 (23): jcs234674.
Published: 02 December 2019
... docking, but also mistargeting of SNARE protein syntaxin1 and an abnormally dense submembrane F-actin network. Here, we tested the contribution of both these phenomena to docking and secretion defects in MUNC18-1-deficient MCCs. We show that an abnormal F-actin network and syntaxin1 targeting defects are...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs221952.
Published: 15 February 2019
...Camille Lenzi; Jennifer Stevens; Daniel Osborn; Matthew J. Hannah; Ruben Bierings; Tom Carter ABSTRACT Elevations of intracellular free Ca 2+ concentration ([Ca 2+ ] i ) are a potent trigger for Weibel–Palade body (WPB) exocytosis and secretion of von Willebrand factor (VWF) from endothelial cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (13): 2159–2171.
Published: 01 July 2017
...Jiaxin Sun; Shiyan Yu; Xiao Zhang; Catherine Capac; Onyedikachi Aligbe; Timothy Daudelin; Edward M. Bonder; Nan Gao ABSTRACT Wntless (Wls) transports Wnt molecules for secretion; however, the cellular mechanism underlying the initial assembly of Wnt secretory vesicles is still not fully defined...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (8): 1355–1363.
Published: 15 April 2017
...Duy T. Tran; Kelly G. Ten Hagen ABSTRACT Real-time imaging of regulated exocytosis in secreting organs can provide unprecedented temporal and spatial detail. Here, we highlight recent advances in 3D time-lapse imaging in Drosophila salivary glands at single-granule resolution. Using fluorescently...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3832–3844.
Published: 15 October 2016
...Charles Campbell; Shawn Beug; Philip E. B. Nickerson; Jimmy Peng; Chantal Mazerolle; Erin A. Bassett; Randy Ringuette; Fadumo A. Jama; Carlos Morales; Annabel Christ; Valerie A. Wallace ABSTRACT Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3868–3877.
Published: 15 October 2016
... machinery in ERES, and a capture model, where cargo freely diffuses into ERES where it is captured by the Sar1 and COPII machinery. Using the novel secretion inhibitor FLI-06, we show that recruitment of the cargo VSVG to ERES is an active process upstream of Sar1 and COPII. Applying FLI-06 before...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (15): 2881–2886.
Published: 01 August 2016
... specialised mechanisms required to facilitate focal signalling and polarised secretion in immune cells. In this Cell Science at a Glance article and the accompanying poster, we illustrate the different steps that reveal the specialised mechanisms used to focus secretion at the CTL immune synapse and allow...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1866–1877.
Published: 01 May 2016
... (NGF) acting through the TrkA neurotrophin receptor (also known as NTRK1) regulates many of these events. However, the molecular mechanisms responsible for NGF-regulated secretion are not completely understood. Here, we describe a new signaling pathway involving TrkA, ARMS (also known as Kidins220...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 706–716.
Published: 15 February 2016
..., COMP also fulfills an important intracellular function in assisting efficient secretion of collagens, which were retained in the endoplasmic reticulum of COMP-null fibroblasts. Accordingly, COMP-null mice showed severely attenuated fibrotic responses in skin. Collagen secretion was fully restored by...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 29–38.
Published: 01 January 2016
...Young Hun Kim; Man Sup Kwak; Jun Bae Park; Shin-Ae Lee; Ji Eun Choi; Hyun-Soo Cho; Jeon-Soo Shin ABSTRACT HMGB1 protein is a delayed mediator of sepsis that is secreted to the extracellular milieu in response to various stimulants, inducing a pro-inflammatory response. HMGB1 is devoid of an...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3398–3410.
Published: 15 September 2015
... 1:1000). Finally, it is interesting to note that Sec61β is required for efficient secretion and is an integral part of the endomembrane system. Work from the Nicchitta laboratory has found that mRNAs that encode endomembrane system components have an enhanced, translation-independent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2330–2338.
Published: 01 July 2015
... for the Aβ-lowering effect of CALHM1. Aβ level reduction by CALHM1 could be explained by an increase in extracellular Aβ degradation by insulin-degrading enzyme (IDE), extracellular secretion of which was strongly potentiated by CALHM1 activation. Importantly, Calhm1 knockout in mice reduced IDE...
Journal Articles
J Cell Sci (2015) 128 (10): 1946–1960.
Published: 15 May 2015
...Na-Ryum Bin; Chang Hun Jung; Byungjin Kim; Prashanth Chandrasegram; Ekaterina Turlova; Dan Zhu; Herbert Y. Gaisano; Hong-Shuo Sun; Shuzo Sugita ABSTRACT Understanding how Munc18 proteins govern exocytosis is crucial because mutations of this protein cause severe secretion deficits in neuronal and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1595–1606.
Published: 15 April 2015
... were analyzed were unaffected. This result indicates a cargo‐specific requirement for GMAP‐210 in secretory trafficking, at least within chondrocytes. A similar phenomenon was seen in our experiments, with different secreted cargoes varying in their sensitivity to GMAP‐210 depletion. The same could...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1193–1203.
Published: 15 March 2015
... crosslinking, and myosin II activity, to contract actin coats and drive secretion. * Author for correspondence ( manfred.frick@uni-ulm.de ) Competing interests The authors declare no competing or financial interests. 3 11 2014 26 01 2015 © 2015. Published by The Company of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (4): 828–844.
Published: 15 February 2014
... VI (COL6), and postulated that ANXA2 directs bronchial epithelial cell secretion of COL6, an unusually large multimeric protein. COL6 serves to anchor cells to basement membranes and, unlike other collagens, undergoes multimerization prior to secretion. Here, we show that AnxA2 −/− mice have reduced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5412–5421.
Published: 01 December 2013
...Eugenia Petoukhov; Sarah Fernando; Fergil Mills; Farhan Shivji; Diana Hunter; Charles Krieger; Michael A. Silverman; Shernaz X. Bamji Summary The secreted growth factor progranulin (PGRN) has been shown to be important for regulating neuronal survival and outgrowth, as well as synapse formation and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4647–4658.
Published: 15 October 2013
... targeted secretion of various matrix metalloproteinases (MMPs). Specifically, MMP2 and MMP9 (MMP2/9) possess the ability to hydrolyze components of the basement membrane and regulate various aspects of tumor growth and metastasis. However, the membrane transport machinery that mediates targeting of MMP2/9...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2931–2943.
Published: 01 July 2013
...Hideki Yamamoto; Chihiro Awada; Hideaki Hanaki; Hiroshi Sakane; Ikuko Tsujimoto; Yuko Takahashi; Toshifumi Takao; Akira Kikuchi Summary Wnts are glycan- and lipid-modified morphogens that are important for cellular responses, but how Wnts are secreted in polarized epithelial cells remains unclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (12): 2704–2717.
Published: 15 June 2013
...Shi Xu; Linlin Ma; Eunbyul Evans; Curtis T. Okamoto; Sarah F. Hamm-Alvarez Summary The polymeric immunoglobulin receptor (pIgR) mediates transcytosis of dimeric immunoglobulin A (dIgA) and its release into mucosal secretions. The present study reveals the complexity of the trafficking of pIgR to...
Includes: Supplementary data