... to dictate the ultimate positioning of daughters is not clear. Here, we identify novel mechanisms of regulation of daughter positioning in single MCF10A cells. The polarity protein, Scribble cooperates with E-cadherin for sequential roles in daughter positioning. First Scribble stabilises E-cadherin...

...Leena Baker; Michael BeGora; Faith Au Yeung; Michael E. Feigin; Avi Z. Rosenberg; Scott W. Lowe; Thomas Kislinger; Senthil K. Muthuswamy ABSTRACT The cell polarity protein scribble (SCRIB) is a crucial regulator of polarization, cell migration and tumorigenesis. Whereas SCRIB is known to regulate...

.... The formation and establishment of epithelial cell polarity is mediated by the cooperation of polarity protein complexes, namely the Crumbs, partitioning defective (Par) and Scribble complexes, with Rho family GTPases, including RhoA, Rac1 and Cdc42. The activation of different GTPases triggers distinct...

...Imogen A. Elsum; Claire Martin; Patrick O. Humbert Summary The crucial role the Crumbs and Par polarity complexes play in tight junction integrity has long been established, however very few studies have investigated the role of the Scribble polarity module. Here, we use MCF10A cells, which fail...

... competition. However, it is not known whether comparable phenomena also occur in mammals. Scribble is a tumor suppressor protein in Drosophila and mammals. In this study we examine the interface between normal and Scribble-knockdown epithelial cells using Madin–Darby Canine Kidney (MDCK) cells expressing...

... exocytosis PC12 cells β-Pix PLD Scribble Rho proteins constitute a subgroup of the small GTPase Ras superfamilly and comprise 20 members that are often involved in membrane trafficking through the remodelling of the actin cytoskeleton ( Ridley, 2006 ). Exocytosis is a fundamental membrane...

...Roger Albertson; Chiswili Chabu; Amy Sheehan; Chris Q. Doe The Drosophila tumor suppressor protein Scribble is required for epithelial polarity, neuroblast polarity, neuroblast spindle asymmetry and limiting cell proliferation. It is a member of the newly described LAP protein family, containing 16...