... Stem cells Skeletal muscle Satellite cell Transcriptome Medical Research Council 10.13039/501100000265 British Heart Foundation 10.13039/501100000274 SP/08/004 Muscular Dystrophy UK RA3/3052 Association Française contre les Myopathies 10.13039...

... in freshly isolated muscle stem cells. These data, together with the analysis of two conditional Ezh2-null mouse strains, identified a critical proliferation phase in which Ezh2 activity is essential. Mice lacking Ezh2 in satellite cells exhibited decreased muscle growth, severely impaired regeneration...

... factors, including the determination genes Myf5 and Myod . The precise role of Myf5 in regulating quiescent muscle stem cells has remained elusive. Here we show that most, but not all, quiescent satellite cells express Myf5 protein, but at varying levels, and that resident Myf5 heterozygous muscle stem...

..., and was transiently expressed in activated, proliferating and differentiating satellite cells (SCs) in injured muscles. Compared with wild-type muscles, Rage −/− muscles exhibited increased numbers of basal SCs that were further increased in injured Rage −/− muscles following elevated myoblast asymmetric division...

[email protected] ) 17 6 2011 © 2011. 2011 Muscular dystrophy PDGFRα Satellite cell Muscle satellite cells are located beneath the basal lamina and begin to proliferate when muscle is damaged ( Charge and Rudnicki, 2004 ). Although muscle satellite cells have great regenerative...

...Yusuke Ono; Viola F. Gnocchi; Peter S. Zammit; Ryoichi Nagatomi Muscle satellite cells are the resident stem cells of adult skeletal muscle. Here, we have examined the role of the multifunctional protein presenilin-1 (PS1) in satellite cell function. PS1 acts as a crucial component of the γ...

...Ramkumar Sambasivan; Sirisha Cheedipudi; NagaRekha Pasupuleti; Amena Saleh; Grace K. Pavlath; Jyotsna Dhawan Quiescent muscle progenitors called satellite cells persist in adult skeletal muscle and, upon injury to muscle, re-enter the cell cycle and either undergo self-renewal or differentiate...

...Anthony Otto; Corina Schmidt; Graham Luke; Steve Allen; Petr Valasek; Francesco Muntoni; Diana Lawrence-Watt; Ketan Patel Satellite cells represent the stem cell population of adult skeletal muscle. The molecular mechanisms that control the proliferation of satellite cells are not well understood...

...Ana Perez-Ruiz; Yusuke Ono; Viola F. Gnocchi; Peter S. Zammit Satellite cells are the resident stem cells of adult skeletal muscle. As with all stem cells, how the choice between self-renewal or differentiation is controlled is central to understanding their function. Here, we have explored...

...Peter S. Zammit; Frederic Relaix; Yosuke Nagata; Ana Pérez Ruiz; Charlotte A. Collins; Terence A. Partridge; Jonathan R. Beauchamp Skeletal muscle growth and regeneration are attributed to satellite cells - muscle stem cells resident beneath the basal lamina that surrounds each myofibre. Quiescent...

.../unit length decreases in larger fibres during skeletal muscle ageing. This leads to an increased size of nuclear domain (quantity of cytoplasm/number of nuclei within that cytoplasm). Initially, larger fibres have more satellite cells than small fibres, but this advantage is lost as satellite cells...

... the activation of satellite cells (SCs) and chemotactic movements of both myoblasts and macrophages ex vivo. Examination of regenerated muscle (28 days after injury) also revealed that Mstn -/- mice showed increased expression of decorin mRNA, reduced fibrosis and improved healing as compared with wild-type mice...

...Chetana Sachidanandan; Ramkumar Sambasivan; Jyotsna Dhawan Myogenic precursor cells known as satellite cells persist in adult skeletal muscle and are responsible for its ability to regenerate after injury. Quiescent satellite cells are activated by signals emanating from damaged muscle. Here we...

... fibres expressed the fluorescence in the cardiotoxin-untreated muscle. Moreover,fluorescence + mononuclear cells were observed beneath the basal lamina of the cardiotoxin-untreated muscle of chimeras, a position where satellite cells are localizing. It was also found that mononuclear fluorescence...

... population survives 25 Gy and forms muscle but not proliferative myogenic cells. * Author for correspondence 25 05 2000 04 04 2000 © 2000 by Company of Biologists 2000 Regeneration Satellite cell Irradiation Notexin Despite its genetic and biochemical homology...

...R. N. Cooper; S. Tajbakhsh; V. Mouly; G. Cossu; M. Buckingham; G. S. Butler-Browne ABSTRACT Regeneration of adult skeletal muscle is an asynchronous process requiring the activation, proliferation and fusion of satellite cells, to form new muscle fibres. This study was designed to determine...

... to the satellite cells of the mammalian muscle, which are likely to be primarily involved in blastema formation and muscle repair, respectively. ≠ Author for correspondence (e-mail: [email protected] ) * Present address: Developmental Biology Research Center, The Randall Institute, King’s College...

... © 1999 by Company of Biologists 1999 Prosome Proteasome Cytoskeleton Satellite cell Myogenesis Sarcomere Satellite cells, also called adult myoblasts or muscle precursor cells, were first described by Mauro (1961) . These mononucleate cells are located between the basement...