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Keywords: SUMOylation
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Journal Articles
J Cell Sci (2021) 134 (17): jcs247171.
Published: 09 September 2021
... that RepoMan (also known as CDCA2), a regulatory subunit of protein phosphatase 1γ (PP1γ) is transiently modified with SUMO-2 at K762 during late telophase. SUMOylation of RepoMan markedly enhanced its binding affinity with lamin A. Moreover, SUMOylated RepoMan contributes to lamin A recruitment to telophase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (13): jcs249771.
Published: 08 July 2021
... stability. SUMOylation SENP3 SENP5 Mitosis Aurora A Spindle assembly Abnormal chromosome segregation causes severe chromosomal instability with numerical or structural abnormalities ( Janssen et al., 2011 ; Soto et al., 2019 ). Precise chromosome segregation requires a well-organized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs220970.
Published: 26 March 2019
... that recruit PML-NB proteins (i.e. PML, DAXX, ATRX, and SUMO-1, SUMO-2 and SUMO-3) to heterochromatin and their functions in H3.3 chromatin assembly. We show that DAXX and PML are recruited to the array through distinct SUMOylation-dependent mechanisms. Additionally, PML is recruited during S phase and its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (1): jcs222612.
Published: 11 January 2019
... of effector proteins, S. Typhimurium resides intracellularly in a specialized vesicle, called the Salmonella -containing vacuole (SCV) that utilizes the host endocytic vesicular transport pathway (VTP). Here, we probed the possible role of SUMOylation, a post-translation modification pathway, in SCV biology...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3794–3804.
Published: 01 September 2014
... (PML)-like nuclear bodies and disturbed sarcomerogenesis. In addition, we show that the skNAC interaction partner Smyd1 contains a putative sumoylation motif and is sumoylated in muscle cells, with depletion of Mms21/Nse2 leading to reduced concentrations of sumoylated Smyd1. Taken together, our data...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 3939–3947.
Published: 01 September 2013
... downregulated the expression of SIRT1 , primarily at the transcriptional level, by reducing the occupancy of the transcriptional activator Sp1 on the proximal promoter of the SIRT1 gene in a SUMOylation-dependent manner. Further analysis revealed that the SUMO E3 ligase PIASy (also known as PIAS4) was induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3713–3723.
Published: 15 August 2013
... is sumoylated and interacts with Ubc9, the only known SUMO-conjugating enzyme. Four functional sumoylation sites lie within the middle domain of TIF1γ, the Smad interaction domain. We show that a sumoylation-defective TIF1γ mutant significantly reduces TIF1γ inhibition of Smad complexes and that of the Smad...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (8): 2064–2074.
Published: 15 April 2012
... of the Su(Hw) insulator. However, high expression of mutant Mod(mdg4)-67.2 completely rescues the insulator activity, indicating that sumoylation is not necessary for enhancer blocking. These results suggest that insulator bodies function as a depot of sumoylated proteins that are involved in insulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 310–316.
Published: 15 January 2012
...Shu-Chin Yip; Sophie Cotteret; Jonathan Chernoff Protein tyrosine phosphatase (PTP)1B is an abundant non-transmembrane enzyme that plays a major role in regulating insulin and leptin signaling. Recently, we reported that PTP1B is inhibited by sumoylation, and that sumoylated PTP1B accumulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2132–2142.
Published: 01 July 2011
... component Endobrevin to the midbody in 786-O cells, leading to defective cytokinesis. Moreover, SUMOylation of pVHL at lysine 171 might modulate its function as a cytokinesis regulator. pVHL tumor suppressor function was also disrupted by the K171G mutation, as evidenced by the xenograft tumor formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (3): 392–400.
Published: 01 February 2010
... 4Pi microscopy Promyelocytic leukemia nuclear bodies Sumoylation PML (promyelocytic leukemia) nuclear bodies (PML-NBs), also referred to as PML oncogenic domain (POD), Nuclear domain-10 (ND10) or Kremer (Kr) bodies, are mobile organelles that form distinct subcompartments in the cell nucleus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2623–2631.
Published: 01 August 2009
..., we also show that TnI is part of the maternal deposit during oogenesis. In cultures of the S2 cell line, native TnI is immunodetected within the nucleus and immunoprecipitated from nuclear extracts. SUMOylation at an identified site is required for the nuclear translocation. These data illustrate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (17): 2930–2938.
Published: 01 September 2008
... surface proteins (VSPs), affecting both antigenic switching and antibody-mediated cell death. During encystation, ADI translocates from the cytoplasm to the nuclei and appears to play a regulatory role in the expression of encystation-specific genes. ADI is also sumoylated, which might modulate its...