... by CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2), a transcriptional coregulator that limits ISG expression by inhibiting STAT1 and IRF1. Here, we show that the closely related Cited1 is an ISG, which is expressed in a STAT1-dependent manner...

...Kezhen Yao; Qi Chen; Yongyan Wu; Fayang Liu; Xin Chen; Yong Zhang ABSTRACT In murine macrophages infected with Mycobacterium tuberculosis ( Mtb ), the level of phosphorylated STAT1 (P-STAT1), which drives the expression of many pro-apoptosis genes, increases quickly but then declines over a period...

... keratinocyte differentiation, and increased expression of immune response genes including the IFN signal transducer STAT1. Loss of RAC1 in keratinocytes decreased actin polymerization in vivo and in vitro and caused Arp2/3-dependent expression of STAT1 , increased interferon sensitivity and upregulation...

... based on an interaction of STAT1 with an interferon-γ-activated site (GAS) within the proximal MVP promoter. Mutation of this site distinctly reduced basal as well as IFN-γ-stimulated MVP transcription. IFN-γ also significantly enhanced the translation rate of MVP. Ectopic MVP overexpression in the MVP...