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Keywords: SPF
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Journal Articles
Ulrich P. Strausfeld, Mike Howell, Patrick Descombes, Stephane Chevalier, Rachel E. Rempel, Jörg Adamczewski, James L. Maller, Tim Hunt, J. Julian Blow
Journal:
Journal of Cell Science
J Cell Sci (1996) 109 (6): 1555–1563.
Published: 1 June 1996
.... Affinity-depletion of cyclin dependent kinases (Cdks) from these extracts blocks the initiation of DNA replication. We define ‘S-phase promoting factor’ (SPF) as the Cdk activity required for DNA replication in these Cdk-depleted extracts. Recombinant cyclins A and E, but not cyclin B, showed significant...
