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Keywords: SPAK
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Journal Articles
J Cell Sci (2011) 124 (9): 1391–1395.
Published: 1 May 2011
... pseudohypoaldosteronism type II (PHAII). Although previous in vitro studies had suggested the existence of a phosphorylation cascade involving the WNK, OSR1 and SPAK kinases, whether the WNK-OSR1/SPAK cascade is in fact fully responsible for NCC phosphorylation in vivo and whether the activation of this cascade...
Journal Articles
J Cell Sci (2008) 121 (20): 3293–3304.
Published: 15 October 2008
...-transduction network that is controlled by WNK kinases. Under hyperosmotic or hypotonic low-Cl – conditions, WNK isoforms are activated, and subsequently phosphorylate and activate the related protein kinases SPAK and OSR1. SPAK and OSR1 phosphorylate and activate ion co-transporters that include NCC, NKCC1...
Journal Articles
J Cell Sci (2008) 121 (5): 675–684.
Published: 1 March 2008
... effectively by thiazide diuretics, which exert their effects by inhibiting the Na + -Cl – cotransporter (NCC), suggesting a link between WNK1 and NCC. Here, we demonstrate that the SPAK and OSR1 kinases that are activated by WNK1 phosphorylate human NCC at three conserved residues (Thr46, Thr55 and Thr60...