... metabolism is unknown. In this study PML NB assembly dynamics were assessed by live cell imaging and mathematic modeling of its major component parts. We show that all six nuclear PML isoforms exhibit individual exchange rates at NBs and identify PML V as a scaffold subunit. SP100 exchanges at least five...

...Dmitri Negorev; Alexander M. Ishov; Gerd G. Maul ABSTRACT Nuclear domains called ND10 or PML nuclear bodies consist of an aggregation of several proteins, most notably PML and Sp100. PML is essential in the nucleation and formation of ND10 as well as in the recruitment of other ND10-associated...

...Hans H. Guldner; Carin Szostecki; Petra Schröder; Urte Matschl; Kirsten Jensen; Cora Lüders; Hans Will; Thomas Sternsdorf ABSTRACT Sp100 and PML are interferon-inducible proteins associated with a new class of nuclear domains (known as nuclear dots or PML bodies) which play a role in tumorigenesis...