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Keywords: SNARES
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Journal Articles
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Membrane trafficking
J Cell Sci (2024) 137 (6): jcs261257.
Published: 19 March 2024
... the abundances of key SNAREs, tethers and Rab proteins. The results suggested that, except for SNAP25 ( Fig. 7A,B ), other candidates did not show a significant change in expression ( Fig. S1E–J ). These findings were consistent with those for another ER stressor, Tm ( Fig. S3G ). Additionally, when we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (12): jcs259576.
Published: 28 June 2022
... trafficking involving SNAREs plays a crucial role in the delivery of cargo to the target membrane. Screening of 13 SNAREs from the endocytic and recycling route using a gene silencing approach coupled with functional assays identified syntaxin 7 (STX7) as an important player in MDA-MB-231 cell invasion. Total...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs244624.
Published: 9 October 2020
..., but the molecular mechanisms underlying this are not known. We identified that a SNARE, Vti1b, is essential for regulating these Ii-induced effects. Vti1b binds to Ii and is localized at the contact sites of fusing Ii-positive endosomes. Furthermore, truncated Ii lacking the cytoplasmic tail, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs246322.
Published: 9 September 2020
... on ESCRT proteins, and fusion-type microautophagy, which requires the core autophagy machinery and SNARE proteins. Many questions remain to be explored, but the functional versatility and mechanistic diversity of microautophagy are beginning to emerge. * Author for correspondence ( [email protected]...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3829–3838.
Published: 15 November 2017
... by recycling to the plasma membrane results in a polarised distribution of membrane proteins by a kinetic mechanism. Here, we report that increasing the volume of residues that constitute the exoplasmic half of the transmembrane domain (TMD) in the yeast SNARE Sso1, a type II membrane protein, results in its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (14): 2817–2828.
Published: 15 July 2016
..., polyphosphate, stimulates binding of the chaperone Sec18/NSF to vacuolar SNAREs, which activates them and triggers fusion. SNAREs can only be activated by lumenal, not cytosolic, polyphosphate (polyP). Control of lumenal polyP over SNARE activation in the cytosol requires the cytosolic cyclin-dependent kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5344–5349.
Published: 1 December 2013
... the Golgi SNARE protein Sft1 and the plasma membrane SNARE protein Sso1 from Saccharomyces cerevisiae as model proteins, we modified the length of their TMDs and the volume of their exoplasmic hemi-TMD, and determined their subcellular localization both in yeast and mammalian cells. We found that short TMDs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (18): 3309–3320.
Published: 15 September 2007
...Thomas Pocard; André Le Bivic; Thierry Galli; Chiara Zurzolo SNARE [soluble N -ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor] proteins control the membrane-fusion events of eukaryotic membrane-trafficking pathways. Specific vesicular and target SNAREs operate in specific...
Includes: Supplementary data
Journal Articles
J Cell Sci (2001) 114 (24): 4397–4405.
Published: 15 December 2001
...Margaret E. Graham; Philip Washbourne; Michael C. Wilson; Robert D. Burgoyne Considerable data support the idea that intracellular membrane fusion involves a conserved machinery containing the SNARE proteins. SNAREs assembled in vitro form a stable 4-helix bundle and it has been suggested...