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Keywords: SNARE
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Journal Articles
J Cell Sci (2020) 133 (18): jcs247148.
Published: 15 September 2020
... growth depends on non-fusogenic Sec22b–Stx1 SNARE complexes at endoplasmic reticulum (ER)–PM contacts. Here, we show that Sec22b interacts with members of the extended synaptotagmin (E-Syt) family of ER lipid transfer proteins (LTPs), and this interaction depends on the longin domain of Sec22b...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (24): jcs222034.
Published: 10 December 2018
... network. Here, we examine its role in the sorting of VAMP7 (also known as TI-VAMP) – an R-SNARE possessing a regulatory longin domain (LD) – into rhodopsin transport carriers (RTCs). During RTC formation and trafficking, VAMP7 colocalizes with the ciliary cargo rhodopsin and interacts with the Rab11...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs212498.
Published: 22 October 2018
...Khamal K. Ampah; Jennifer Greaves; Amber S. Shun-Shion; Asral W. Asnawi; Jessica A. Lidster; Luke H. Chamberlain; Mark O. Collins; Andrew A. Peden ABSTRACT STX19 is an unusual Q a -SNARE as it lacks a C-terminal transmembrane domain. However, it is efficiently targeted to post-Golgi membranes. Here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs202838.
Published: 29 January 2018
...Kin Pan Chung; Yonglun Zeng; Yimin Li; Changyang Ji; Yiji Xia; Liwen Jiang; Jenny Russinova ABSTRACT Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs) are well-known for their role in controlling membrane fusion, the final, but crucial step, in vesicular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (8): 1421–1434.
Published: 15 April 2017
... trafficking. To understand the evolutionary history of trypanosomatid trafficking, where multiple lifestyles and mechanisms of host interactions are known, we examined protein families central to defining intracellular compartments and mediating transport, namely Rabs, SNAREs and RabGAPs, across all available...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (7): 1285–1298.
Published: 01 April 2017
... oxidatively damaged NOX2. We identified syntaxin-7, SNAP23 and VAMP8 as the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins mediating this process. Our data describe a key mechanism of how dendritic cells sustain ROS production after antigen uptake that is required...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4263–4272.
Published: 01 December 2015
...Frédéric Daste; Thierry Galli; David Tareste ABSTRACT Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins constitute the core membrane fusion machinery of intracellular transport and intercellular communication. A little more than ten years ago, it was proposed...
Journal Articles
J Cell Sci (2015) 128 (15): 2891–2902.
Published: 01 August 2015
... that are dependent on clathrin and those that are not. The SNARE proteins VAMP2, VAMP3 and VAMP8 are internalized in a clathrin-dependent manner. However, the full scope of their endocytic behavior has not yet been elucidated. Here, we found that VAMP2, VAMP3 and VAMP8 are localized on plasma membrane invaginations...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1946–1960.
Published: 15 May 2015
...@uhnres.utoronto.ca ) Competing interests The authors declare no competing or financial interests. 4 11 2014 16 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 Exocytosis Mast cell Membrane trafficking Munc18 Secretion SNARE Munc18-2 (also known as STXBP2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3745–3756.
Published: 01 September 2014
... (SNAREs). Although SNARE complexes are fairly promiscuous in vitro , substantial specificity is achieved in cells owing to the spatial segregation and shielding of SNARE motifs prior to association with cognate Q-SNAREs. In this study, we identified phosphatidylinositol 4-kinase IIα (PI4K2A) as a binding...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1712–1725.
Published: 15 April 2014
... by syntaxin13 (officially known as STX12) and SNAP23; a similar dependence on these two SNARE proteins was observed for invadopodium-based matrix degradation and cell invasion. Inhibition of SNARE function impaired the delivery of Src and EGFR to developing invadopodia, as well as the β1-integrin-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3134–3140.
Published: 15 July 2013
...Aram Megighian; Mauro Zordan; Sergio Pantano; Michele Scorzeto; Michela Rigoni; Damiano Zanini; Ornella Rossetto; Cesare Montecucco Summary The SNARE proteins VAMP/synaptobrevin, SNAP-25 and syntaxin are core components of the apparatus that mediates neurotransmitter release. They form...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2914–2923.
Published: 01 July 2013
... attachment protein receptor (SNARE) protein assembly. To monitor dynamic changes in syntaxin 1A (Syx) conformation along exocytosis, we constructed a novel fluorescent Syx-based probe that can be efficiently incorporated within endogenous SNARE complexes, support exocytosis, and report shifts in Syx between...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2361–2371.
Published: 01 June 2013
...Gayoung Anna Han; Na-Ryum Bin; Soo-Young Ann Kang; Liping Han; Shuzo Sugita Summary Munc18-1 is believed to prime or stimulate SNARE-mediated membrane fusion/exocytosis through binding to the SNARE complex, in addition to chaperoning its cognate syntaxins. Nevertheless, a Munc18-1 mutant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1506–1516.
Published: 15 March 2013
...Orly Laufman; WanJin Hong; Sima Lev Summary Multisubunit tethering complexes (MTCs) positively regulate vesicular fusion by as yet unclear mechanism. In this study we provide evidence that the MTC COG enhances the assembly of fusogenic Golgi SNARE complexes and concomitantly prevents nonfusogenic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (16): 3827–3839.
Published: 15 August 2012
.... The expression and distribution of integrins at the cell surface is controlled by endocytosis and recycling. The present study examines the function of syntaxin 6 (STX6), a t-SNARE located in the trans-Golgi network, in integrin trafficking. STX6 is overexpressed in many types of human cancer. We show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1683–1692.
Published: 01 April 2012
...Surya Karunakaran; Terry Sasser; Sailasree Rajalekshmi; Rutilio A. Fratti Homotypic vacuole fusion requires SNAREs, the Rab Ypt7p, the tethering complex HOPS, regulatory lipids and actin. In Saccharomyces cerevisiae , actin functions at two stages of vacuole fusion. Pre-existing actin filaments...
Journal Articles
J Cell Sci (2011) 124 (18): 3066–3073.
Published: 15 September 2011
... for correspondence ( joerg.breustedt@charite.de ; dietmar.schmitz@charite.de ) 9 5 2011 © 2011. 2011 GABA B receptor Metabotropic Neurotransmission Energy barrier SNARE Presynaptic inhibition Metabotropic signalling through γ-aminobutyric acid B receptors (GABA B R) has been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (19): 3266–3275.
Published: 01 October 2010
... was impaired on nhx1 Δ vacuoles, SNARE complex formation was indistinguishable from wild-type vacuoles. Fusion could be rescued by adding the soluble SNARE Vam7p. However, Vam7p only activated the first round of nhx1 Δ vacuole fusion. Once fusion was initiated, nhx1 Δ vacuoles appeared behave in a wild-type...
Journal Articles
J Cell Sci (2010) 123 (19): 3276–3283.
Published: 01 October 2010
... SNAP-25 in which Arg206 had been replaced by alanine. Electrophysiological recordings of spontaneous and evoked neurotransmitter release under different conditions as well as testing for the assembly of the SNARE complex indicate that this residue, which is at the P 1 ′ position of the botulinum...
Includes: Supplementary data