... . 10.1111/j.1742-4658.2007.06110.x Carducci , M. , Perfetto , L. , Briganti , L. , Paoluzi , S. , Costa , S. , Zerweck , J. , Schutkowski , M. , Castagnoli , L. and Cesareni , G. ( 2012 ). The protein interaction network mediated by human SH3 domains...

.... The functional role of the different protein interaction domains is not well understood. Here we show that Drosophila Dap160 lacking the dynamin-binding SH3 domains does not affect the development of the neuromuscular junction but plays a key role in synaptic vesicle recycling. dap160 mutants lacking dynamin...

...) is crucial for Src-induced podosome formation. Using an inducible system for Src activation, we found that Src-induced podosome formation depends upon the Src SH3 domain, and identified Arhgef5 as a Src SH3-binding protein. RNA interference (RNAi)-mediated depletion of Arhgef5 caused robust inhibition of Src...

...Susumu Antoku; Bruce J. Mayer Crk family adaptors, consisting of Src homology 2 (SH2) and SH3 protein-binding domains, mediate assembly of protein complexes in signaling. CrkI, an alternately spliced form of Crk, lacks the regulatory phosphorylation site and C-terminal SH3 domain present in CrkII...

... that mediate the initial attachment of cells and initiate Rac activation and lamellipodia extension. It was absent from focal complexes and focal adhesions, the integrin complexes that mediate adhesion in lamellipodia and fully spread cells. Spectrin contains a Src homology (SH3) domain of unknown function...

... recruit and modulate the actin machinery and ultimately regulate cell migration. 7 10 2004 © The Company of Biologists Limited 2005 2005 Cortactin N-WASP SH3 domain Cell migration Actin polymerization Cell migration is critical for many physiological processes...

...-terminus of AP-180, which inhibited transferrin uptake, had no effect on EGF-induced internalization of EGFR. YFP-tagged Grb2 containing an inhibitory mutation in either N- or C-SH3 domain redistributed to the plasma membrane upon EGF stimulation, but the macropinocytic structures containing Grb2-YFP...

... of the PRD of FasL with an SH3-domain-containing protein, enables direct sorting of FasL from the Golgi to secretory lysosomes. Fas ligand (FasL) is a member of the tumour necrosis factor (TNF) family ( Schneider et al., 1998 ; Tanaka et al., 1998 ). This 40 kDa membrane protein is expressed by activated...

... family suggest a general function in recruitment of the interacting proteins to sites of endocytosis. * Author for correspondence (e-mail: [email protected] ) 16 11 2000 04 10 2000 © 2000 by Company of Biologists 2000 SH3 domain Proline-rich motif NPF motif...

...: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, Korea © 2000 by Company of Biologists 2000 Postsynaptic density Cell junction PDZ domain SH3 domain Ankyrin repeat SAM domain Homer Cortactin Glutamate receptor GKAP PSD-95...

... terminus of tau interacts with the SH3 domains of fyn and src non-receptor tyrosine kinases. Tau and fyn were co-immunoprecipitated from human neuroblastoma cells and co-localization of tau and fyn was visualized in co-transfected NIH3T3 cells. Co-transfection of tau and fyn also resulted in an alteration...

... 07 07 1998 © 1998 by Company of Biologists 1998 Actin Adherens junction Cadherin Cdc42 Cell adhesion HeLa Myosin-I Myr 3 Rac SH3 domain Myosin molecules exert directed force along actin filaments and therefore are functionally linked to the cellular organization...

...Lewis C. Cantley; Zhou Songyang ABSTRACT SH2 domains and SH3 domains, found in a number of protein-tyrosine kinases and substrates of protein-tyrosine kinases, provide specificity in downstream signaling. Both of these domains bind to relatively short linear sequences of peptides to provide...