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Keywords: SARA
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Journal Articles
J Cell Sci (2015) 128 (3): 487–498.
Published: 01 February 2015
... of control cells, despite a temporal extension of Smad2 phosphorylation. We assessed SARA–Smad2–Smad4 association and observed that knockdown of aPKC increased SARA (also known as ZFYVE9) levels and SARA–Smad2 complex formation, increased cytoplasmic retention of Smad2 and reduced Smad2–Smad4 complex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3209–3222.
Published: 01 October 2011
...George Sflomos; Eleftherios Kostaras; Ekaterini Panopoulou; Nikolaos Pappas; Athena Kyrkou; Anastasia S. Politou; Theodore Fotsis; Carol Murphy SARA, an early endosomal protein, plays a key role in TGFβ signalling, as it presents SMAD2 and SMAD3 for phosphorylation by the activated TGFβ receptors...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (7): 1216–1224.
Published: 01 April 2007
...Weibin Shi; Chenbei Chang; Shuyi Nie; Shutao Xie; Mei Wan; Xu Cao Signaling through receptors of the transforming growth factor β (TGFβ) superfamily is mediated by cytoplasmic Smad proteins. It has been demonstrated that Smad anchor for receptor activation (SARA) facilitates TGFβ and activin/nodal...
Journal Articles
J Cell Sci (2002) 115 (24): 4755–4763.
Published: 15 December 2002
...-kinases and FYVE domain proteins, such as EEA1, can be recruited onto early endosomes and act as Rab5 effectors. SARA (Smad anchor for receptor activation), also a FYVE domain protein, was initially isolated as a participant in signal transduction from the transforming growth factorβ receptor...