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Keywords: S-acylation
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Journal Articles
J Cell Sci (2022) 135 (5): jcs258579.
Published: 22 June 2021
... channels. Although the importance of CRAC channels is well described, the underlying mechanisms that regulate the recruitment of Orai1 to ER–PM junctions are not fully understood. Here, we describe the rapid and transient S-acylation of Orai1. Using biochemical approaches, we show that Orai1 is rapidly S...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs258186.
Published: 3 June 2021
...Shayahati Bieerkehazhi; Ying Fan; Savannah J. West; Ritika Tewari; Junsuk Ko; Tingting Mills; Darren Boehning; Askar M. Akimzhanov ABSTRACT Despite the recognized significance of reversible protein lipidation (S-acylation) for T cell receptor signal transduction, the enzymatic control of this post...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (22): jcs251819.
Published: 17 November 2020
... in the eukarya domain, with 23 distinct zDHHC-encoding genes in the human genome. zDHHC enzymes mediate the bulk of S-acylation (also known as palmitoylation) reactions in cells, transferring acyl chains to cysteine thiolates, and in so-doing affecting the stability, localisation and function of several thousand...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (1997) 110 (5): 673–679.
Published: 1 March 1997
...P. Zlatkine; B. Mehul; A. I. Magee ABSTRACT Several members of the Src family of protein tyrosine kinases have a N-terminal dual acylation motif which specifies their myristoylation and S-acylation. These lipid modifications are necessary for correct intracellular localisation to the plasma...