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Keywords: Ryanodine receptor
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J Cell Sci (2020) 133 (6): jcs240879.
Published: 19 March 2020
.../endoplasmic reticulum Ca 2+ -ATPase (SERCA) pump and of the ryanodine receptor leak were too modest to explain the large changes seen in [Ca 2+ ] SR . Instead, these changes are compatible with increased leakiness through the ryanodine receptor as the main determinant of the [Ca 2+ ] SR decline in aging...
Includes: Supplementary data
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J Cell Sci (2019) 132 (4): jcs222463.
Published: 14 December 2018
... similar analyses of ryanodine receptors, have contributed to understanding IP 3 R behaviour. Analyses of permeabilized cells have demonstrated that the ER is the major intracellular Ca 2+ store, and that IP 3 stimulates Ca 2+ release from this store. Radioligand binding confirmed that the 4,5-phosphates...
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J Cell Sci (2014) 127 (12): 2782–2792.
Published: 15 June 2014
... similarity with a conserved sequence present in all three ryanodine receptor (RyR) isoforms. We now report that Bcl-2 co-immunoprecipitated with RyRs in ectopic expression systems and in native rat hippocampi, indicating that endogenous RyR–Bcl-2 complexes exist. Purified RyR domains containing the putative...
Includes: Supplementary data
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J Cell Sci (2013) 126 (15): 3485–3492.
Published: 1 August 2013
...Mirko Vukcevic; Francesco Zorzato; Simone Keck; Dimitrios A. Tsakiris; Jennifer Keiser; Rick M. Maizels; Susan Treves Summary Mutations in RYR1 , the gene encoding ryanodine receptor 1, are linked to a variety of neuromuscular disorders including malignant hyperthermia (MH), a pharmacogenetic...
Includes: Supplementary data
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J Cell Sci (2011) 124 (7): 1167–1174.
Published: 1 April 2011
...Meredith N. Schulson; David R. L. Scriven; Patrick Fletcher; Edwin D. W. Moore Standard local control theory, which describes Ca 2+ release during excitation–contraction coupling (ECC), assumes that all ryanodine receptor 2 (RyR2) complexes are equivalent. Findings from our laboratory have called...
Includes: Supplementary data
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J Cell Sci (2006) 119 (11): 2386–2397.
Published: 1 June 2006
...Spyros Zissimopoulos; Duncan J. West; Alan J. Williams; F. Anthony Lai The ryanodine receptor (RyR) is a widely expressed intracellular calcium (Ca 2+ )-release channel regulating processes such as muscle contraction and neurotransmission. Snapin, a ubiquitously expressed SNARE-associated protein...
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J Cell Sci (2005) 118 (23): 5637–5646.
Published: 1 December 2005
... is important for adrenergic-mediated hypertrophy. One function of the mAKAP complex is to facilitate cAMP-dependent protein kinase A-catalyzed phosphorylation of the ryanodine receptor Ca 2+ -release channel. Experiments utilizing inhibition of the ryanodine receptor, RNA interference of mAKAP expression...
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J Cell Sci (2005) 118 (20): 4613–4619.
Published: 15 October 2005
...Jonathan-Lee Jones; Deborah F. Reynolds; F. Anthony Lai; Lynda M. Blayney Ryanodine receptor (RyR) Ca 2+ release channels undergo a conformational change between the open and closed states. Its protein modulator, FK506 binding protein 12 (FKBP12), stabilises the channel gating between the four...
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J Cell Sci (2004) 117 (15): 3087–3094.
Published: 1 July 2004
...): all three messengers are equally able to reduce the Ca 2+ concentration inside the NE and this is associated with a transient rise in the nucleoplasmic Ca 2+ concentration. The NE contains ryanodine receptors (RyRs) and Ins(1,4,5) P 3 receptors [Ins(1,4,5) P 3 Rs], and these can be activated...
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