... ; llewelyn.roderick@bbsrc.ac.uk ) © The Company of Biologists Limited 2009 2009 Calcium Gene transcription Ins P 3 Nucleus Paclitaxel Ryanodine Signalling Spindle checkpoint Taxol Calcium (Ca 2+ ) is a key player in signal transduction. It modulates diverse cellular activities ranging from...

... influx of Ca 2+ provokes more substantial Ca 2+ release from closely apposed ryanodine receptor (RyR) clusters on the SR by a process known as Ca 2+ -induced Ca 2+ release (CICR) ( Callewaert, 1992 ; Roderick et al., 2003 ). The essential elementary events underlying EC-coupling are `Ca 2+ sparks...

...Julia V. Gerasimenko; Mark Sherwood; Alexei V. Tepikin; Ole H. Petersen; Oleg V. Gerasimenko Inositol trisphosphate and cyclic ADP-ribose release Ca 2+ from the endoplasmic reticulum via inositol trisphosphate and ryanodine receptors, respectively. By contrast, nicotinic acid adenine dinucleotide...

... (MA) muscles differentially control expression of the slow myosin heavy chain 2 (slow MyHC2 ) gene. We report here that slow MyHC2 gene expression in fast PM muscle fibers is repressed by endogenous activity of the ryanodine receptor 1 (RyR1). Inhibition of RyR1 with ryanodine led to expression...